Document Detail


A vasculature-associated niche for undifferentiated spermatogonia in the mouse testis.
MedLine Citation:
PMID:  17823316     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mammalian spermatogenesis produces numerous sperm for a long period based on a highly potent stem cell system, which relies on a special microenvironment, or niche, that has not yet been identified. In this study, using time-lapse imaging of green fluorescent protein-labeled undifferentiated spermatogonia (A(undiff)) and three-dimensional reconstitution, we revealed a biased localization of A(undiff) to the vascular network and accompanying Leydig and other interstitial cells, in intact testes. Differentiating spermatogonia left these niche regions and dispersed throughout the basal compartment of the seminiferous epithelium. Moreover, rearrangement of A(undiff) accompanied the vasculature alteration. We propose that the mammalian germline niche is established as a consequence of vasculature pattern formation. This is different from what is observed in Drosophila or Caenorhabditis elegans, which display developmentally specified niche structures within polarized gonads.
Authors:
Shosei Yoshida; Mamiko Sukeno; Yo-Ichi Nabeshima
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-09-06
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  317     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-21     Completed Date:  2007-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1722-6     Citation Subset:  IM    
Affiliation:
Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. shosei@lmls.med.kyoto-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Basic Helix-Loop-Helix Transcription Factors / genetics
Blood Vessels / cytology
Green Fluorescent Proteins
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Nerve Tissue Proteins / genetics
Seminiferous Tubules / blood supply,  cytology
Spermatogenesis
Spermatogonia / cytology*
Testis / blood supply,  cytology*
Chemical
Reg. No./Substance:
0/Basic Helix-Loop-Helix Transcription Factors; 0/Nerve Tissue Proteins; 0/Neurog3 protein, mouse; 147336-22-9/Green Fluorescent Proteins
Comments/Corrections
Comment In:
Science. 2007 Sep 21;317(5845):1696-7   [PMID:  17885122 ]

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