Document Detail

The vascular pathogenesis of gastroschisis: intrauterine interruption of the omphalomesenteric artery.
MedLine Citation:
PMID:  6450826     Owner:  NLM     Status:  MEDLINE    
Recognition of the disruptive vascular nature of the structural defects associated with gastroschisis and an appreciation of the embryology of the umbilical region suggest that gastroschisis results from an intrauterine interruption of the omphalomesenteric artery. This mechanism accounts for the usual location of gastroschisis to the right of the umbilical cord, the integrity of the rectus muscles in affected children, and many of the clinically observed differences between gastroschisis and omphalocele. The vascular basis of this defect explains its negligible recurrence risk and should alert the clinician to the possibility of concomitant structural defects of a similar pathogenesis.
H E Hoyme; M C Higginbottom; K L Jones
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  98     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1981 Feb 
Date Detail:
Created Date:  1981-04-13     Completed Date:  1981-04-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  228-31     Citation Subset:  AIM; IM    
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MeSH Terms
Abdominal Muscles / abnormalities
Abnormalities, Multiple / complications*
Hernia, Ventral / congenital,  embryology*
Infant, Newborn
Maternal-Fetal Exchange
Mesenteric Arteries / embryology*
Mesenteric Vascular Occlusion / embryology*

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