Document Detail

The vascular endothelium in normal pregnancy and pre-eclampsia.
MedLine Citation:
PMID:  9414447     Owner:  NLM     Status:  MEDLINE    
Hypertensive disorders of pregnancy affect up to 15% of pregnancies and the most severe form, pre-eclampsia, is the leading cause of maternal death in the UK today. Pre-eclampsia is a multisystem disorder affecting virtually every organ and system in the body, with hypertension and proteinuria, the traditional diagnostic features, representing two facets of a complex pathophysiological process. The common pathological feature of the disease, whether in the decidual vessels of the placental bed, renal microvasculature, liver, heart or cerebral circulation, is vascular endothelial damage and dysfunction. Before new ways of preventing or ameliorating hypertensive disorders of pregnancy can be found, we must first understand the pathophysiological mechanisms underlying the clinical problem. This review summarizes the evidence that endothelial dysfunction plays a key role in hypertensive disorders of pregnancy and will focus on the most severe form, pre-eclampsia.
F Lyall; I A Greer
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Reviews of reproduction     Volume:  1     ISSN:  1359-6004     ISO Abbreviation:  Rev. Reprod.     Publication Date:  1996 May 
Date Detail:
Created Date:  1998-01-14     Completed Date:  1998-01-14     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9602351     Medline TA:  Rev Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  107-16     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, University of Glasgow, Glasgow Royal Infirmary, UK.
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MeSH Terms
Blood Platelets / physiology
Endothelium, Vascular / physiology*
Lipids / physiology
Neutrophil Activation / physiology
Nitric Oxide / physiology
Pre-Eclampsia / physiopathology*
Pregnancy / physiology*
Prostaglandins / physiology
Reg. No./Substance:
0/Lipids; 0/Prostaglandins; 10102-43-9/Nitric Oxide

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