| The vascular endothelium in normal pregnancy and pre-eclampsia. | |
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MedLine Citation:
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PMID: 9414447 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypertensive disorders of pregnancy affect up to 15% of pregnancies and the most severe form, pre-eclampsia, is the leading cause of maternal death in the UK today. Pre-eclampsia is a multisystem disorder affecting virtually every organ and system in the body, with hypertension and proteinuria, the traditional diagnostic features, representing two facets of a complex pathophysiological process. The common pathological feature of the disease, whether in the decidual vessels of the placental bed, renal microvasculature, liver, heart or cerebral circulation, is vascular endothelial damage and dysfunction. Before new ways of preventing or ameliorating hypertensive disorders of pregnancy can be found, we must first understand the pathophysiological mechanisms underlying the clinical problem. This review summarizes the evidence that endothelial dysfunction plays a key role in hypertensive disorders of pregnancy and will focus on the most severe form, pre-eclampsia. |
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Authors:
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F Lyall; I A Greer |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Reviews of reproduction Volume: 1 ISSN: 1359-6004 ISO Abbreviation: Rev. Reprod. Publication Date: 1996 May |
Date Detail:
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Created Date: 1998-01-14 Completed Date: 1998-01-14 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9602351 Medline TA: Rev Reprod Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 107-16 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, University of Glasgow, Glasgow Royal Infirmary, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Platelets
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physiology Endothelium, Vascular / physiology* Female Humans Lipids / physiology Neutrophil Activation / physiology Nitric Oxide / physiology Pre-Eclampsia / physiopathology* Pregnancy / physiology* Prostaglandins / physiology |
| Chemical | |
Reg. No./Substance:
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0/Lipids; 0/Prostaglandins; 10102-43-9/Nitric Oxide |
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