Document Detail


A variety of opportunities for immune interactions during trophoblast development and invasion.
MedLine Citation:
PMID:  22593844     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
During human implantation and placentation, the direct cell to cell contact of fetal and maternal tissues gives room for a variety of immune interactions. Especially, the invasion of a subset of fetal trophoblast cells, called extravillous trophoblast, generate a very close interplay between the two individuals, enabling the attachment of the placenta to the uterine wall and the transformation of maternal spiral arteries to facilitate adequate nutrition of the fetus. During pregnancy, maternal and fetal factors closely interact to maintain pregnancy and smooth the process of delivery. At each and every stage and site, immunological interactions take place, including attachment of the blastocyst, development and invasion of trophoblast, and flow of maternal plasma and blood through the intervillous space of the placenta. Control mechanisms tightly regulate these interactions helping to evade fetal rejection by the mother. In this review, we highlight the morphological sites of development and feto-maternal interaction to help immunological interested scientists and clinicians to develop hypotheses on the feto-maternal immunological network during pregnancy.
Authors:
Berthold Huppertz; Veronika M Berghold; Rie Kawaguchi; Martin Gauster
Related Documents :
16900384 - Neonatal disease in neutral endopeptidase alloimmunization: lessons for immunological m...
16524324 - Early first-trimester sibutramine exposure : pregnancy outcome and neonatal follow-up.
3295284 - Sonographic biophysical profile in the postdate pregnancy.
23375234 - Is the placental disk really an ellipse?
16740524 - Elective single embryo transfer in women aged 36-39 years.
23761484 - Modulation of dna methylation states and infant immune system by dietary supplementatio...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  67     ISSN:  1600-0897     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  349-57     Citation Subset:  IM    
Affiliation:
Institute of Cell Biology, Histology and Embryology, Medical University of Graz, Austria. berthold.huppertz@medunigraz.at
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  ENGAGE: Guided Activity-Based Gaming in Neurorehabilitation after Stroke: A Pilot Study.
Next Document:  Blood transfusion utilization and recipient survival at Hospital das Clinicas in São Paulo, Brazil.