Document Detail


The variegate neurological manifestations of varicella zoster virus infection.
MedLine Citation:
PMID:  23884722     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Varicella zoster virus (VZV) is an exclusively human neurotropic alphaherpesvirus. Primary infection causes varicella (chickenpox), after which the virus becomes latent in ganglionic neurons along the entire neuraxis. With advancing age or immunosuppression, cell-mediated immunity to VZV declines, and the virus reactivates to cause zoster (shingles), dermatomal distribution, pain, and rash. Zoster is often followed by chronic pain (postherpetic neuralgia), cranial nerve palsies, zoster paresis, vasculopathy, meningoencephalitis, and multiple ocular disorders. This review covers clinical, laboratory, and pathological features of neurological complications of VZV reactivation, including diagnostic testing to verify active VZV infection in the nervous system. Additional perspectives are provided by discussions of VZV latency, animal models to study varicella pathogenesis and immunity, and of the value of vaccination of elderly individuals to boost cell-mediated immunity to VZV and prevent VZV reactivation.
Authors:
Don Gilden; Maria A Nagel; Randall J Cohrs; Ravi Mahalingam
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current neurology and neuroscience reports     Volume:  13     ISSN:  1534-6293     ISO Abbreviation:  Curr Neurol Neurosci Rep     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-07-25     Completed Date:  2014-03-27     Revised Date:  2014-06-11    
Medline Journal Info:
Nlm Unique ID:  100931790     Medline TA:  Curr Neurol Neurosci Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  374     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Disease Models, Animal
Herpes Zoster / diagnosis,  immunology,  virology*
Herpesvirus 3, Human / physiology*
Humans
Nervous System Diseases / virology*
Neuralgia, Postherpetic / immunology,  virology*
Virus Latency / physiology
Grant Support
ID/Acronym/Agency:
AG006127/AG/NIA NIH HHS; AG032958/AG/NIA NIH HHS; K08 NS067070/NS/NINDS NIH HHS; NS067070/NS/NINDS NIH HHS; NS082228/NS/NINDS NIH HHS; P01 AG032958/AG/NIA NIH HHS; R01 AG006127/AG/NIA NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Immunomodulatory effects of IL-12 released from poly-N-acetyl glucosamine gel matrix during schistos...
Next Document:  Daptomycin underexposure in a young intravenous drug user who was affected by life-threatening Staph...