Document Detail


A variant of position -308 of the Tumour necrosis factor alpha gene promoter and the risk of coronary heart disease.
MedLine Citation:
PMID:  17581788     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The aim of this study was to investigate whether the variability between individuals with coronary heart disease (CHD) is related to the prevalence of TNF-alpha gene promoter -308 variant in un-matched British Caucasian population from East Midlands. PROCEDURES: Genotypes and allele frequencies were determined using restriction fragment length polymorphism analysis of polymerase chain reaction (PCR) products. Genomic DNA prepared from peripheral blood leukocytes of patients (n=97) and healthy controls (n=95) demonstrated two alleles TNF*1 (G) and TNF*2 (A). FINDINGS: The genotype distribution in patients was GG, n=59; GA, n=36; and AA, n=2 and in controls was GG, n=41; GA, n=40; and AA, n=14 (P=0.014). The association analysis demonstrated that TNF*1 allele in patients appears to be associated with greater incidences of CHD (OR 2.15; CI, 1.36-3.39; P=0.001). CONCLUSIONS: Our results suggest that TNF*1 allele (TNF-alpha -308 GG or GA) has a high prevalence among British Caucasian population that correlates with an increased CHD risk.
Authors:
Maqsood M Elahi; Ashley Gilmour; Bashir M Matata; Sarabjit S Mastana
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Publication Detail:
Type:  Journal Article     Date:  2007-06-19
Journal Detail:
Title:  Heart, lung & circulation     Volume:  17     ISSN:  1444-2892     ISO Abbreviation:  Heart Lung Circ     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2007-12-18     Completed Date:  2008-03-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100963739     Medline TA:  Heart Lung Circ     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  14-8     Citation Subset:  IM    
Affiliation:
Department of Human Sciences, Loughborough University, Loughborough LE11 3TU, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Age Distribution
Aged
Case-Control Studies
Confidence Intervals
Coronary Angiography
Coronary Disease / epidemiology*,  genetics*,  radiography
European Continental Ancestry Group / genetics*
Female
Gene Frequency
Genetic Predisposition to Disease / epidemiology*
Great Britain / epidemiology
Humans
Incidence
Male
Middle Aged
Odds Ratio
Pilot Projects
Polymorphism, Genetic*
Probability
Prognosis
Promoter Regions, Genetic
Reference Values
Risk Assessment
Sex Distribution
Tumor Necrosis Factor-alpha / genetics*
Chemical
Reg. No./Substance:
0/Tumor Necrosis Factor-alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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