| A variant of long QT syndrome manifested as fetal tachycardia and associated with ventricular septal defect. | |
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MedLine Citation:
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PMID: 10455095 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two patients with a novel variant of long QT syndrome are described. The clinical course was characterised by an in utero onset of ventricular tachycardia and atrioventricular block (at 26 and 30 weeks' gestational age, respectively), and an association with a ventricular septal defect. Studies of both patients' families identified relatives with prolonged QT interval, syncope, or sudden death. One patient died of intractable ventricular tachycardia at 4 days old. The other received beta blocker treatment and a pacemaker. She died suddenly at the age of 10 months. The unique association with ventricular septal defect and the malignant clinical course warrants further molecular diagnosis of this novel variant of long QT syndrome. |
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Authors:
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M H Wu; F C Hsieh; J K Wang; M L Kau |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Heart (British Cardiac Society) Volume: 82 ISSN: 1468-201X ISO Abbreviation: Heart Publication Date: 1999 Sep |
Date Detail:
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Created Date: 1999-10-07 Completed Date: 1999-10-07 Revised Date: 2008-11-20 |
Medline Journal Info:
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Nlm Unique ID: 9602087 Medline TA: Heart Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 386-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, National Taiwan University Hospital, No 7, Chung-Shen South Road, Taipei, Taiwan 100. mhwu@ha.mc.ntu.edu.tw |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Fetal Diseases / genetics* Heart Septal Defects, Ventricular / genetics* Humans Infant, Newborn Long QT Syndrome / genetics* Pedigree Tachycardia, Ventricular / genetics* |
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