| A variant at chromosome 9p21 is associated with recurrent myocardial infarction and cardiac death after acute coronary syndrome: the GRACE Genetics Study. | |
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MedLine Citation:
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PMID: 20231156 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: Recent genetic studies identified the rs1333049 variant on chromosome 9p21 as a major susceptibility locus for coronary artery disease and myocardial infarction (MI). Here, we evaluated whether this variant also contributes to recurrent MI or cardiac death following an acute coronary syndrome (ACS). METHODS AND RESULTS: A total of 3247 patients with ACS enrolled in the Global Registry of Acute Coronary Events (GRACE) in three distinct populations (UK, Belgium and Poland) were prospectively followed for 6 months and genotyped for rs1333049, in addition to 3004 and 2467 healthy controls from the UK and Belgium. After having confirmed that the at-risk C allele of rs1333049 was associated with index ACS in the UK and Belgian populations, we found that the rs1333049 at-risk C allele was significantly and independently associated with recurrent MI [age- and gender-adjusted hazard ratio (HR) 1.48, CI = 1.00-2.19, P = 0.048; and multivariable-adjusted HR 1.47, CI = 0.99-2.18; P = 0.053] and with recurrent MI or cardiac death (age- and gender-adjusted HR 1.58, CI = 1.00-2.48; P = 0.045; and multivariable adjusted HR 1.49, CI = 1.03-1.98; P = 0.028) within 6 months after an index ACS. Inclusion of rs1333049 into the GRACE risk score significantly improved classification for recurrent MI or cardiac death (P = 0.040), as calculated by the integrated discrimination improvement method. CONCLUSION: In this large observational study, the 9p21 variant was independently associated with adverse cardiac outcome after ACS. |
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Authors:
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Ian Buysschaert; Kathryn F Carruthers; Donald R Dunbar; Gilian Peuteman; Ernst Rietzschel; Ann Belmans; Ann Hedley; Tim De Meyer; Andrzej Budaj; Frans Van de Werf; Diether Lambrechts; Keith A A Fox |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Date: 2010-03-15 |
Journal Detail:
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Title: European heart journal Volume: 31 ISSN: 1522-9645 ISO Abbreviation: Eur. Heart J. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-03 Completed Date: 2011-04-29 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: England |
Other Details:
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Languages: eng Pagination: 1132-41 Citation Subset: IM |
Affiliation:
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Vesalius Research Center, VIB and KULeuven, Campus Gasthuisberg, Herestraat 49, Box 912, B-3000 Leuven, Belgium. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Coronary Syndrome
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genetics* Aged Chromosomes, Human, Pair 9 / genetics* Death, Sudden, Cardiac / etiology* Female Genes, p16* Genetic Predisposition to Disease / genetics Genetic Testing Genotype Hospitalization Humans Male Middle Aged Myocardial Infarction / genetics* Polymorphism, Single Nucleotide / genetics Prospective Studies Recurrence Registries Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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076113//Wellcome Trust; CH/92010//British Heart Foundation; //Canadian Institutes of Health Research |
| Comments/Corrections | |
Comment In:
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Eur Heart J. 2010 May;31(9):1038-40
[PMID:
20233791
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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