Document Detail

A variable valve area, lumped parameter model of left ventricular filling.
MedLine Citation:
PMID:  12085655     Owner:  NLM     Status:  MEDLINE    
A variable valve lumped parameter model was developed and validated in porcine trials. The model was used to simulate ventricular and atrial pressures and flows during diastolic filling. The variable valve area model simulations provide reasonable results and take into account other considerations like venous inflow and initial valve aperture. Comparisons between model outputs and in-vivo porcine experiments suggest that the model may be used in the future to assess compliance and effective orifice area based on parameters derived from non-invasive Doppler waveforms.
Davis Soans; Gabor Szabo; Charissa Bolind; Lee Waite
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies    
Journal Detail:
Title:  Biomedical sciences instrumentation     Volume:  38     ISSN:  0067-8856     ISO Abbreviation:  Biomed Sci Instrum     Publication Date:  2002  
Date Detail:
Created Date:  2002-06-27     Completed Date:  2002-11-06     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0140524     Medline TA:  Biomed Sci Instrum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  483-8     Citation Subset:  IM    
Department of Applied Biology and Biomedical Engineering, Rose-Hulman Institute of Technology, Terre Haute, IN 47803, USA.
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MeSH Terms
Blood Flow Velocity
Blood Pressure / physiology
Computer Simulation
Diastole / physiology
Mitral Valve / physiology*,  ultrasonography
Models, Animal
Models, Cardiovascular*
Ventricular Function, Left / physiology*

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