| The variable plasma quercetin response to 12-week quercetin supplementation in humans. | |
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MedLine Citation:
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PMID: 20517329 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/OBJECTIVES: Quercetin supplementation results in a variable plasma quercetin response in humans. The purpose of this study was to determine whether this variance is related to gender, age, body mass index (BMI), and other demographic and lifestyle factors. SUBJECTS/METHODS: Subjects (N=1002, ages 18-85 years, 60% female and 40% male) were recruited from the community and randomized to one of three groups, with supplements administered using double-blinded procedures: Q-500 (500 mg/day), Q-1000 (1000 mg/day), or placebo. Subjects ingested two soft chew supplements twice daily during the 12-week study. Fasting blood samples were obtained pre- and post-study, analyzed for plasma quercetin, and then compared between and within groups by gender, age group (<40, 40-59, and >or=60 years), BMI (<25, 25-29.9, and >or=30 kg/m(2)), self-reported physical fitness level, and diet intake (food group servings). RESULTS: Quercetin supplementation over 12 weeks caused a significant increase in overnight-fasted plasma quercetin, with a net increase of 332+/-21.0 and 516+/-30.8 microg/l for Q-500 and Q-1000 compared with 53.6+/-6.4 microg/l for placebo (interaction effect, P<0.001). The increase in plasma quercetin was highly variable within each quercetin supplementation group, but was unrelated to age, gender, BMI, fitness levels, or diet intake. CONCLUSIONS: In summary, quercetin supplementation in doses of 500 and 1000 mg/day caused large but highly variable increases in plasma quercetin that were unrelated to demographic or lifestyle factors. |
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Authors:
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F Jin; D C Nieman; R A Shanely; A M Knab; M D Austin; W Sha |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2010-06-02 |
Journal Detail:
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Title: European journal of clinical nutrition Volume: 64 ISSN: 1476-5640 ISO Abbreviation: Eur J Clin Nutr Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-07 Completed Date: 2011-01-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8804070 Medline TA: Eur J Clin Nutr Country: England |
Other Details:
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Languages: eng Pagination: 692-7 Citation Subset: IM |
Affiliation:
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Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Body Constitution* Dietary Supplements* Dose-Response Relationship, Drug Double-Blind Method Female Humans Male Middle Aged Plant Extracts* / administration & dosage, blood, pharmacology Quercetin* / administration & dosage, blood, pharmacology Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Plant Extracts; 117-39-5/Quercetin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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