Document Detail

The variable effects of angiotensin converting enzyme inhibition on myocardial ischaemia in chronic stable angina.
MedLine Citation:
PMID:  2548548     Owner:  NLM     Status:  MEDLINE    
The effect of angiotensin converting enzyme inhibition on myocardial ischaemia was studied in 12 normotensive patients with chronic stable angina and exercise induced ST segment depression. The study was randomised, double blind, placebo controlled, and crossover with treatment periods of two weeks. Enalapril was used to inhibit angiotensin converting enzyme. Assessment was by angina diaries and maximum symptom limited treadmill exercise tests. The results for the whole group showed a significant reduction in systolic blood pressure at rest and at peak exercise. Mean total exercise duration was 466 s (95% confidence interval 406 to 525) when the patients were taking placebo and 509 s (436 to 583) when they were taking enalapril. Four patients prolonged their total exercise time (mean 450 to mean 591 s) by more than 20%. Two patients, however, developed ischaemia earlier on exercise and reduced their total exercise duration (mean 490 to mean 390 s). Although angiotensin converting enzyme inhibition tended to reduce myocardial ischaemia in the group as a whole, some patients improved while others deteriorated. Thus the effects of enalapril are variable and this may have important implications when enalapril is used to treat heart failure in patients with underlying severe ischaemic heart disease.
J Simon; R Gibbs; P A Crean; L Mockus; C Wright; G C Sutton; K M Fox
Related Documents :
2859798 - Addition of nifedipine to maximal nitrate and beta-adrenoreceptor blocker therapy in co...
1346268 - Efficacy of epanolol versus metoprolol in angina pectoris: report from a swedish multic...
3019118 - Prolonged hemodynamic effect of a slow-release nitroglycerin ointment.
11099758 - Reduction of latent inhibition by d-amphetamine in a conditioned suppression paradigm i...
12453168 - Does physical exercise in addition to a multicomponent smoking cessation program increa...
7153128 - In vivo leucine oxidation at rest and during two intensities of exercise.
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British heart journal     Volume:  62     ISSN:  0007-0769     ISO Abbreviation:  Br Heart J     Publication Date:  1989 Aug 
Date Detail:
Created Date:  1989-10-11     Completed Date:  1989-10-11     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370634     Medline TA:  Br Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  112-7     Citation Subset:  AIM; IM    
National Heart Hospital, London.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Angina Pectoris / drug therapy,  physiopathology*
Chronic Disease
Coronary Circulation / drug effects
Coronary Disease / physiopathology*
Double-Blind Method
Enalapril / pharmacology*,  therapeutic use
Exercise Test
Hemodynamics / drug effects
Middle Aged
Nitroglycerin / therapeutic use
Random Allocation
Reg. No./Substance:
55-63-0/Nitroglycerin; 75847-73-3/Enalapril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Gonadotropin, as a tumor marker, in body fluid and tumor tissues of germ cell tumors
Next Document:  Automatic control of neuromuscular block with atracurium.