Document Detail

The variability of delivered dose of aerosols with the same respirable concentration but different size distributions.
MedLine Citation:
PMID:  12176709     Owner:  NLM     Status:  MEDLINE    
The influences of aerosol size distribution and breath tidal volume on respirable dose estimates were examined for mouth breathing using the ACGIH/ISO/CEN criterion for respirable-equivalent aerosols. Actual tissue doses predicted from a set of pulmonary empirical deposition equations, the Heyder-Rudolf equations, were compared with deposition assumed to occur under the penetration-based respirable dust sampling criterion. Deposition estimate errors ranged from approximately 1/10- to 10-fold, with aerosol mass median aerodynamic equivalent diameter and geometric standard deviation as well as tidal volume each showing a substantial influence under appropriate conditions. These findings demonstrate that reliance on respirable aerosol sampling data obtained with devices performing on a penetration-based sampling criterion may lead to erroneous dose-response relationships in exposure standard development as well as exposure misclassification errors during epidemiological studies. A more reliable dose estimate would be obtained using devices with collection efficiency performance closely matching the alveolar deposition prediction curves of Heyder and Rudolf. We believe that if it is not currently required, the development of a deposition-based aerosol sampling methodology will soon be required for the determination and quantification of inhaled aerosol-induced adverse health effects.
N A Esmen; D L Johnson; G M Agron
Related Documents :
7315739 - A model for aerosol deposition in the human tracheobronchial region.
11502159 - A biomathematical model of particle clearance and retention in the lungs of coal miners...
7462609 - Aerosol deposition in the respiratory tract of the rat. experimental results and mathem...
11980279 - Methodological aspects in the analysis of spontaneously produced sputum.
2748219 - Expression of results of histamine challenge.
19683119 - The rusch viewmax vs macintosh laryngoscopy in human cadavers: impoved vocal cord visua...
21441219 - Sexy but often unreliable: the impact of unreliability on the replicability of experime...
8074739 - Empirical test of an ion parametric resonance model for magnetic field interactions wit...
11290729 - Bayesian mapping of quantitative trait loci under complicated mating designs.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Annals of occupational hygiene     Volume:  46     ISSN:  0003-4878     ISO Abbreviation:  Ann Occup Hyg     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-08-14     Completed Date:  2002-09-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0203526     Medline TA:  Ann Occup Hyg     Country:  England    
Other Details:
Languages:  eng     Pagination:  401-7     Citation Subset:  IM    
Aerosols Research Laboratory, University of Oklahoma Health Sciences Centre, PO Box 26901, Oklahoma City 73190, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aerosols / administration & dosage*
Drug Delivery Systems*
Particle Size
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Exposure to cooking fumes in restaurant kitchens in norway.
Next Document:  Comparison by X-ray diffraction and infrared spectroscopy of two samples of alpha quartz with the NI...