Document Detail

The value of upsloping ST depression in diagnosing myocardial ischemia.
MedLine Citation:
PMID:  16846438     Owner:  NLM     Status:  MEDLINE    
We evaluated the value of upsloping ST-segment depression in predicting the severity of myocardial ischemia. Comparison of the exercise electrocardiographic changes was made to myocardial perfusion images and coronary angiograms as the criteria for ischemia. We retrospectively reviewed 621 patients who underwent exercise technetium-99m tetrofosmin single photon emission computed tomography (SPECT) for the assessment of suspected or known coronary artery disease followed by coronary angiography within a 3-month period. The test sensitivity and specificity of 1 mm horizontal or downsloping ST depression in predicting reversible ischemia as assessed by gated SPECT imaging (GSI) were 65% and 87%, respectively. The corresponding values were 67% and 94% compared to coronary angiography. The sensitivity and specificity of gated SPECT imaging compared to coronary angiography were 78% and 89%. On the other hand when 1 mm upsloping ST depression at 70 ms past the J-point was regarded as abnormal, along with horizontal and downsloping, the sensitivity and specificity were 82% and 90% compared to myocardial perfusion imaging, and 77% and 92% as assessed by coronary angiography. We conclude that upsloping ST-segment depression is associated with an increased risk of coronary artery disease and is a valuable predictor of myocardial ischemia.
George Polizos; Myrvin H Ellestad
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc     Volume:  11     ISSN:  1082-720X     ISO Abbreviation:  Ann Noninvasive Electrocardiol     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-18     Completed Date:  2006-11-21     Revised Date:  2008-03-10    
Medline Journal Info:
Nlm Unique ID:  9607443     Medline TA:  Ann Noninvasive Electrocardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  237-40     Citation Subset:  IM    
Long Beach Memorial Medical Center, Heart Institute, CA, USA.
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MeSH Terms
Coronary Angiography
Exercise Test
Myocardial Ischemia / diagnosis*
Organophosphorus Compounds
Organotechnetium Compounds
Retrospective Studies
Sensitivity and Specificity
Tomography, Emission-Computed, Single-Photon
Reg. No./Substance:
0/Organophosphorus Compounds; 0/Organotechnetium Compounds; 0/Radiopharmaceuticals; 0/technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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