| The value of the thyrotropin-releasing hormone test in patients with prolactin-secreting pituitary tumors and suprasellar non-pituitary tumors. | |
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MedLine Citation:
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PMID: 6781936 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The prolactin (PRL) response to thyrotropin-releasing hormone (TRH) (delta PRL) was normal in 7 (18%) of 38 patients with clinical evidence of a prolactinoma. A negative percentage correlation between basal PRL and delta PRL was found (P less than 0.05), but a percentage correlation between tumor size and delta PRL was absent. In a survey of literature concerning 548 patients, delta PRL after TRH administration amounted to 100% or more of the basal value in 11% of patients with clinical evidence of a prolactinoma and in 9% with an adenoma proven by surgery. Hyperprolactinemia was also present in 12 of our 21 patients (57%) with suprasellar tumors not related to pituitary tumors. In 7 of 11 of these hyperprolactinemic patients (64%), the PRL response to TRH was decreased. In conclusion, the TRH test may be helpful but is not decisive in the diagnostic work-up of hyperprolactinemia patients. |
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Authors:
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J G Klijn; S W Lamberts; F H de Jong; J C Birkenhäger |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Fertility and sterility Volume: 35 ISSN: 0015-0282 ISO Abbreviation: Fertil. Steril. Publication Date: 1981 Feb |
Date Detail:
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Created Date: 1981-05-13 Completed Date: 1981-05-13 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 155-61 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acromegaly
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diagnosis Diagnosis, Differential Dose-Response Relationship, Drug Female Humans Male Neoplasms / secretion Oligospermia / diagnosis Pituitary Neoplasms / secretion* Prolactin / blood, secretion* Sella Turcica / secretion* Thyrotropin-Releasing Hormone / diagnostic use*, pharmacology Time Factors |
| Chemical | |
Reg. No./Substance:
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24305-27-9/Thyrotropin-Releasing Hormone; 9002-62-4/Prolactin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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