| The value of switching from cyclosporine to tacrolimus in the treatment of refractory acute rejection and obliterative bronchiolitis after lung transplantation. | |
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MedLine Citation:
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PMID: 11875609 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Standard cyclosporine-based immunosuppression is ineffective in the treatment of refractory acute rejection (RAR) and obliterative bronchiolitis (OB) that follows lung transplantation. The aim of this study was to evaluate the results of switching from cyclosporine to tacrolimus in the treatment of these situations. Nineteen patients entered the study. The indication for switching was OB in 11 patients and RAR in 8. Mean age was 41.3 +/- 13.1 years. In patients with RAR, the number of acute rejections was 1.5 +/- 0.7 and there were zero episodes per patient per 100 days before and after switching, respectively ( P = 0.02). There was no significant reduction of the decline of forced expiratory volume (FEV(1)) within 6 months after switching in patients with OB. We conclude that the conversion from cyclosporine to tacrolimus was associated with favourable results in the treatment of RAR. Further studies are required to assess the influence of this approach in the treatment of OB. |
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Authors:
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Kambiz Sarahrudi; Angelo Carretta; Wilfried Wisser; Omer Senbaklavaci; Meinhard Ploner; Petra Neuhauser; Michael Dobrovits; Gabriel Miwai Marta; Andras Papp; Walter Klepetko |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2002-01-18 |
Journal Detail:
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Title: Transplant international : official journal of the European Society for Organ Transplantation Volume: 15 ISSN: 0934-0874 ISO Abbreviation: Transpl. Int. Publication Date: 2002 Jan |
Date Detail:
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Created Date: 2002-03-04 Completed Date: 2002-07-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8908516 Medline TA: Transpl Int Country: Germany |
Other Details:
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Languages: eng Pagination: 24-8 Citation Subset: IM |
Affiliation:
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Department of Cardiothoracic Surgery, University of Vienna, Währinger Gürtel 18-20, 1090, Austria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Bronchiolitis Obliterans / drug therapy* Cyclosporine / therapeutic use* Female Graft Rejection / drug therapy* Humans Immunosuppressive Agents / therapeutic use* Lung Transplantation / adverse effects* Male Tacrolimus / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 109581-93-3/Tacrolimus; 59865-13-3/Cyclosporine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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