Document Detail


The value of switching from cyclosporine to tacrolimus in the treatment of refractory acute rejection and obliterative bronchiolitis after lung transplantation.
MedLine Citation:
PMID:  11875609     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Standard cyclosporine-based immunosuppression is ineffective in the treatment of refractory acute rejection (RAR) and obliterative bronchiolitis (OB) that follows lung transplantation. The aim of this study was to evaluate the results of switching from cyclosporine to tacrolimus in the treatment of these situations. Nineteen patients entered the study. The indication for switching was OB in 11 patients and RAR in 8. Mean age was 41.3 +/- 13.1 years. In patients with RAR, the number of acute rejections was 1.5 +/- 0.7 and there were zero episodes per patient per 100 days before and after switching, respectively ( P = 0.02). There was no significant reduction of the decline of forced expiratory volume (FEV(1)) within 6 months after switching in patients with OB. We conclude that the conversion from cyclosporine to tacrolimus was associated with favourable results in the treatment of RAR. Further studies are required to assess the influence of this approach in the treatment of OB.
Authors:
Kambiz Sarahrudi; Angelo Carretta; Wilfried Wisser; Omer Senbaklavaci; Meinhard Ploner; Petra Neuhauser; Michael Dobrovits; Gabriel Miwai Marta; Andras Papp; Walter Klepetko
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2002-01-18
Journal Detail:
Title:  Transplant international : official journal of the European Society for Organ Transplantation     Volume:  15     ISSN:  0934-0874     ISO Abbreviation:  Transpl. Int.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-03-04     Completed Date:  2002-07-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8908516     Medline TA:  Transpl Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  24-8     Citation Subset:  IM    
Affiliation:
Department of Cardiothoracic Surgery, University of Vienna, Währinger Gürtel 18-20, 1090, Austria.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Bronchiolitis Obliterans / drug therapy*
Cyclosporine / therapeutic use*
Female
Graft Rejection / drug therapy*
Humans
Immunosuppressive Agents / therapeutic use*
Lung Transplantation / adverse effects*
Male
Tacrolimus / therapeutic use*
Chemical
Reg. No./Substance:
0/Immunosuppressive Agents; 109581-93-3/Tacrolimus; 59865-13-3/Cyclosporine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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