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The value of serum fibrinogen level in the diagnosis of acute appendicitis.
MedLine Citation:
PMID:  23188598     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: The aim of this study was to investigate the importance of serum fibrinogen level in the diagnosis of acute appendicitis.
METHODS: This study was performed on 201 patients who admitted to our clinic. Symptoms, signs, duration of symptoms, and laboratory indicators of appendicitis were recorded, in keeping with the Alvarado score for acute appendicitis. The ultimate diagnosis was based on histopathological results. Serum fibrinogen levels were detected before surgery. The sensitivity, specificity, and predictive values of single test and test combinations were calculated at different cut-off levels.
RESULTS: During the study period, 201 patients underwent surgery for suspected acute appendicitis. Appendicitis was confirmed in 179 (89%) patients. The mean age was 24.8±7.7 (range, 20-57) years, and 154 (76.6%) patients were male and 47 (23.4%) female. The best diagnostic cut-off point for fibrinogen was found at 245.5 mg/dl, for white blood cells (WBC) at 11,900x109/L and for Alvarado score at 7.
CONCLUSION: The use of fibrinogen blood level may be a new diagnostic acute-phase reactant in the diagnosis of acute appendicitis. The formulation of a triple test is recommended as criteria in deciding emergency surgery or observation.
Authors:
Oner Menteş; Mehmet Eryılmaz; Ali Harlak; Erkan Oztürk; Turgut Tufan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES     Volume:  18     ISSN:  1306-696X     ISO Abbreviation:  Ulus Travma Acil Cerrahi Derg     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-11-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101274231     Medline TA:  Ulus Travma Acil Cerrahi Derg     Country:  Turkey    
Other Details:
Languages:  eng     Pagination:  384-8     Citation Subset:  IM    
Affiliation:
Depertment of General Surgery, Gülhane Military Medical Faculty, Ankara, Turkey. onermentes@yahoo.com.
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