Document Detail

The value of pronuclear scoring for the success of IVF and ICSI-cycles.
MedLine Citation:
PMID:  16333679     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Pronuclear scoring helps to identify good quality embryos already at the pronuclear stage. There are no data available, however, to demonstrate whether patients benefit from a higher pregnancy rate after pronuclear scoring. METHODS: In a retrospective, matched cohort study 338 cycles in which patients chose to score their oocytes at the pronuclear stage (scoring group) were compared with 338 cycles without scoring (control group). The cycles were matched for maternal age, number of previous IVF and ICSI cycles, cryopreservation (yes/no) and diagnosis of primary infertility. RESULTS: The pregnancy rate was not significantly different between the scoring group and the control group (24.0 vs. 21.0%, NS) in spite of more cycles with grade A embryos and a higher number of embryos transferred. The presence of a Z1 pronuclear oocyte was found to be associated with the retrieval of more oocytes, a higher fertilization rate and more grade A embryos, as well as a non-significant increase in pregnancy rates (25.1 vs. 18.8%). CONCLUSIONS: Benefit from pronuclear scoring seems to be small. Apparently, experienced biologists are able to select "good-quality" pronuclear oocytes in the same way they would do after scoring. However, the results might be biased by differences between the groups.
A K Ludwig; S Werner; K Diedrich; B Nitz; M Ludwig
Related Documents :
9572429 - Increase in transforming growth factor beta1 in ovarian follicular fluid following ovar...
16412739 - Successful ongoing pregnancies after vitrification of oocytes.
16274599 - Criteria to assess human oocyte quality after cryopreservation.
11278209 - Administration of cyclophosphamide at different stages of follicular maturation in mice...
12831599 - Preimplantation genetic diagnosis for familial dysautonomia.
12217319 - An essential role for functional telomeres in mouse germ cells during fertilization and...
9589339 - Experience of violence among teenage mothers in alaska.
19701759 - Comparison between human fetal and adult skin.
14707749 - Nonobstetric surgery during pregnancy: what are the risks of anesthesia?
Publication Detail:
Type:  Journal Article     Date:  2005-12-07
Journal Detail:
Title:  Archives of gynecology and obstetrics     Volume:  273     ISSN:  0932-0067     ISO Abbreviation:  Arch. Gynecol. Obstet.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-02-27     Completed Date:  2008-07-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710213     Medline TA:  Arch Gynecol Obstet     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  346-54     Citation Subset:  IM    
Department of Gynecology and Obstetrics, University Clinic Schleswig-Holstein , Campus Lübeck, Ratzeburger Allee 160, 23538 Lubeck, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cell Nucleus Division
Cell Survival
Cohort Studies
Fertilization in Vitro*
Maternal Age
Oocytes / physiology*
Predictive Value of Tests
Pregnancy Rate
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  5-Fluorouracil can cross brain-blood barrier and cause encephalopathy: should we expect the same fro...
Next Document:  Autonomic nervous activity changes in relation to the reporting of subjective symptoms among male wo...