Document Detail

The value of pronuclear scoring for the success of IVF and ICSI-cycles.
MedLine Citation:
PMID:  16333679     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Pronuclear scoring helps to identify good quality embryos already at the pronuclear stage. There are no data available, however, to demonstrate whether patients benefit from a higher pregnancy rate after pronuclear scoring. METHODS: In a retrospective, matched cohort study 338 cycles in which patients chose to score their oocytes at the pronuclear stage (scoring group) were compared with 338 cycles without scoring (control group). The cycles were matched for maternal age, number of previous IVF and ICSI cycles, cryopreservation (yes/no) and diagnosis of primary infertility. RESULTS: The pregnancy rate was not significantly different between the scoring group and the control group (24.0 vs. 21.0%, NS) in spite of more cycles with grade A embryos and a higher number of embryos transferred. The presence of a Z1 pronuclear oocyte was found to be associated with the retrieval of more oocytes, a higher fertilization rate and more grade A embryos, as well as a non-significant increase in pregnancy rates (25.1 vs. 18.8%). CONCLUSIONS: Benefit from pronuclear scoring seems to be small. Apparently, experienced biologists are able to select "good-quality" pronuclear oocytes in the same way they would do after scoring. However, the results might be biased by differences between the groups.
A K Ludwig; S Werner; K Diedrich; B Nitz; M Ludwig
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Publication Detail:
Type:  Journal Article     Date:  2005-12-07
Journal Detail:
Title:  Archives of gynecology and obstetrics     Volume:  273     ISSN:  0932-0067     ISO Abbreviation:  Arch. Gynecol. Obstet.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-02-27     Completed Date:  2008-07-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710213     Medline TA:  Arch Gynecol Obstet     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  346-54     Citation Subset:  IM    
Department of Gynecology and Obstetrics, University Clinic Schleswig-Holstein , Campus Lübeck, Ratzeburger Allee 160, 23538 Lubeck, Germany.
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MeSH Terms
Cell Nucleus Division
Cell Survival
Cohort Studies
Fertilization in Vitro*
Maternal Age
Oocytes / physiology*
Predictive Value of Tests
Pregnancy Rate
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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