| The value of pronuclear scoring for the success of IVF and ICSI-cycles. | |
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MedLine Citation:
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PMID: 16333679 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Pronuclear scoring helps to identify good quality embryos already at the pronuclear stage. There are no data available, however, to demonstrate whether patients benefit from a higher pregnancy rate after pronuclear scoring. METHODS: In a retrospective, matched cohort study 338 cycles in which patients chose to score their oocytes at the pronuclear stage (scoring group) were compared with 338 cycles without scoring (control group). The cycles were matched for maternal age, number of previous IVF and ICSI cycles, cryopreservation (yes/no) and diagnosis of primary infertility. RESULTS: The pregnancy rate was not significantly different between the scoring group and the control group (24.0 vs. 21.0%, NS) in spite of more cycles with grade A embryos and a higher number of embryos transferred. The presence of a Z1 pronuclear oocyte was found to be associated with the retrieval of more oocytes, a higher fertilization rate and more grade A embryos, as well as a non-significant increase in pregnancy rates (25.1 vs. 18.8%). CONCLUSIONS: Benefit from pronuclear scoring seems to be small. Apparently, experienced biologists are able to select "good-quality" pronuclear oocytes in the same way they would do after scoring. However, the results might be biased by differences between the groups. |
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Authors:
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A K Ludwig; S Werner; K Diedrich; B Nitz; M Ludwig |
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Publication Detail:
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Type: Journal Article Date: 2005-12-07 |
Journal Detail:
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Title: Archives of gynecology and obstetrics Volume: 273 ISSN: 0932-0067 ISO Abbreviation: Arch. Gynecol. Obstet. Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-02-27 Completed Date: 2008-07-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710213 Medline TA: Arch Gynecol Obstet Country: Germany |
Other Details:
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Languages: eng Pagination: 346-54 Citation Subset: IM |
Affiliation:
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Department of Gynecology and Obstetrics, University Clinic Schleswig-Holstein , Campus Lübeck, Ratzeburger Allee 160, 23538 Lubeck, Germany. A.K.Ludwig@web.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cell Nucleus Division Cell Survival Cohort Studies Female Fertilization* Fertilization in Vitro* Humans Maternal Age Oocytes / physiology* Predictive Value of Tests Pregnancy Pregnancy Rate Retrospective Studies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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