| The value of prior information for detection of QTL affecting longitudinal traits: an example using Von Bertalanffy growth function. | |
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MedLine Citation:
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PMID: 16130487 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A Bayesian procedure is presented for detecting quantitative trait loci (QTL) affecting longitudinal traits. The statistical model assumes a QTL affecting the prior distribution of the parameters of a given production function, under a hierarchical Bayesian scheme. Marginal posterior distributions for the effects associated with the QTL are calculated using Markov chain Monte Carlo methods. Furthermore, the Bayesian analysis allows the use of some available relevant information that can improve the detection of the QTL substantially. To illustrate the procedure, an example of QTL detection using the Von Bertalanffy growth function is presented with a F2 pig population bred from Iberian boars and Landrace sows. Animals of the F2 population were genotyped for seven markers in chromosome 2 (SSC2). Two prior distributions for the mean effect of the parameters related with birth and adult weight were compared. On the one hand, vague prior distributions were used, and, on the other, there were assumed univariate Gaussian distributions that ensure biologically meaningful adult and birth weights on the posterior growth curves. Results from the second prior distribution supported the presence of QTL, by showing that individuals with both alleles of Iberian origin had lower rates of maturation. On the contrary, when vague priors were used, the procedure was not able to detect QTL. |
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Authors:
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L Varona; L Gómez-Raya; W M Rauw; C Ovilo; A Clop; J L Noguera |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of animal breeding and genetics = Zeitschrift für Tierzüchtung und Züchtungsbiologie Volume: 122 ISSN: 0931-2668 ISO Abbreviation: J. Anim. Breed. Genet. Publication Date: 2005 Feb |
Date Detail:
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Created Date: 2005-08-31 Completed Date: 2005-09-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100955807 Medline TA: J Anim Breed Genet Country: Germany |
Other Details:
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Languages: eng Pagination: 37-48 Citation Subset: IM |
Affiliation:
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Area de Producció Animal, Centre UdL-IRTA, Lleida, Spain. luis.varona@irta.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bayes Theorem Body Weight / genetics* Genetic Markers Genotype Markov Chains Models, Genetic Models, Statistical Monte Carlo Method Quantitative Trait Loci / genetics* Swine / genetics*, growth & development* |
| Chemical | |
Reg. No./Substance:
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0/Genetic Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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