Document Detail

The value of pre-treatment with gonadotrophin releasing hormone (GnRH) analogue in IVF-ET therapy of severe endometriosis.
MedLine Citation:
PMID:  2113929     Owner:  NLM     Status:  MEDLINE    
Controversy concerning the optimal treatment of endometriosis and its related infertility still exists. Thirty-one women with moderate and severe endometriosis, who failed to conceive during previous in-vitro fertilization and embryo transfer (IVF-ET) cycles (protocol A), were re-admitted for the procedure following a period of hormonal suppression with a gonadotrophin releasing-hormone (GnRH) agonist (protocol B). Following GnRH analogue treatment, a significantly higher number of oocytes were recovered (P less than 0.0006); consequently more embryos were transferred and significantly higher clinical pregnancy rates per cycle (P less than 0.0001) were achieved. This difference may be directly related to the beneficial effect of the GnRH analogue on pelvic endometriosis, converting severe cases into mild ones with improved ovarian accessibility and probably oocyte quality.
D Dicker; G A Goldman; J Ashkenazi; D Feldberg; I Voliovitz; J A Goldman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  5     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-08-08     Completed Date:  1990-08-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  418-20     Citation Subset:  IM    
Sherman Fertility Institute, Golda Meir Medical Centre, Hasharon Hospital, Petah Tikva, Israel.
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MeSH Terms
Buserelin / therapeutic use*
Embryo Transfer*
Endometriosis / complications*
Fertilization in Vitro*
Infertility, Female / drug therapy*,  etiology
Oocytes / drug effects
Reg. No./Substance:

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