Document Detail

The value of peritoneal fluid hypoxanthine besides lactic acid in detection of the vascular compromise of intestine.
MedLine Citation:
PMID:  8323921     Owner:  NLM     Status:  MEDLINE    
Hypoxanthine has been shown to be a sensitive and more specific measure of hypoxia than lactate in several body fluids other than peritoneal fluid. An experimental study was conducted to determine the value of peritoneal fluid hypoxanthine besides lactic acid levels in detecting vascular compromise of the intestine. Thirty male guinea pigs were divided in 3 groups each containing 10 animals. Groups comprised of sham operation control, simple intestinal obstruction and intestinal obstruction with vascular compromise. Lactic acid and hypoxanthine levels were determined in peritoneal lavage effluents. Peritoneal fluid lactic acid levels increased after 4 hours of intestinal obstruction with vascular compromise (p < 0.01) but not in simple intestinal obstruction and sham operation control groups. No detectable amount of hypoxanthine could be found in any of the fluid samples. It is concluded that unlike in other body fluids hypoxanthine is not present in peritoneal fluid and does not become evident after vascular compromise of the intestine.
F M Akgür; K Kulinç; T Aktuğ
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie     Volume:  3     ISSN:  0939-7248     ISO Abbreviation:  Eur J Pediatr Surg     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-08-12     Completed Date:  1993-08-12     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9105263     Medline TA:  Eur J Pediatr Surg     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  72-4     Citation Subset:  IM    
Department of Pediatric Surgery, Dokuz Eylül University, Medical Faculty, Izmir, Turkey.
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MeSH Terms
Ascitic Fluid / metabolism*
Guinea Pigs
Hypoxanthines / metabolism*
Ileal Diseases / diagnosis,  metabolism
Intestinal Obstruction / diagnosis,  metabolism
Intestines / blood supply*
Ischemia / diagnosis*,  metabolism
Lactates / metabolism*
Lactic Acid
Mesenteric Arteries
Mesenteric Vascular Occlusion / diagnosis,  metabolism
Mesenteric Veins
Uric Acid / metabolism
Reg. No./Substance:
0/Hypoxanthines; 0/Lactates; 50-21-5/Lactic Acid; 68-94-0/Hypoxanthine; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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