Document Detail

The value of interphase cytogenetics in cytology for the diagnosis of leptomeningeal metastases.
MedLine Citation:
PMID:  9748058     Owner:  NLM     Status:  MEDLINE    
We studied the use of fluorescence in situ hybridization (FISH) in CSF to enhance the diagnostic yield for the detection of malignancy on the first lumbar puncture in patients clinically suspected of having leptomeningeal metastases (LMM). Although repeated lumbar punctures were still needed in some patients, the use of FISH did speed up the diagnosis in approximately one-third of the patients clinically suspected of having LMM with atypical cells at first cytology. This eliminates the need for repeated lumbar punctures in these patients and enables an earlier start of treatment.
R J van Oostenbrugge; A H Hopman; J W Arends; F C Ramaekers; A Twijnstra
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurology     Volume:  51     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-10-20     Completed Date:  1998-10-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  906-8     Citation Subset:  AIM; IM    
Department of Neurology, University Hospital Maastricht, The Netherlands.
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MeSH Terms
Cerebrospinal Fluid / cytology*
Cytogenetics / methods*
In Situ Hybridization, Fluorescence
Meningeal Neoplasms / cerebrospinal fluid,  diagnosis*,  genetics,  secondary*
Predictive Value of Tests

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