| The value of early second trimester PAPP-A and ADAM12 in screening for pre-eclampsia. | |
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MedLine Citation:
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PMID: 22357350 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To estimate the pre-eclampsia screening performance of PAPP-A (pregnancy-associated plasma protein-A) and ADAM12 (A Disintegrin And Metalloprotease 12) in the early second trimester of pregnancy. METHODS: Stored frozen serum samples from a previously published nested case-control study comprising 77 women who developed pre-eclampsia and 224 unaffected controls were thawed and assayed for PAPP-A and ADAM12. Levels were converted into multiple of the unaffected median (MoM) values. RESULTS: Neither PAPP-A or ADAM12 were significantly different in women who developed pre-eclamspia compared with unaffected controls (PAPP-A: 0.97 MoM [95% confidence interval 0.73 to 1.25], ADAM12: 1.01 MoM [0.91 to 1.13]). CONCLUSION: Our results do not support the use of PAPP-A or ADAM12 in early second trimester antenatal screening for pre-eclampsia. |
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Authors:
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Jonathan P Bestwick; Lynne M George; Tiesheng Wu; Joan K Morris; Nicholas J Wald |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-22 |
Journal Detail:
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Title: Journal of medical screening Volume: - ISSN: 1475-5793 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9433359 Medline TA: J Med Screen Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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