| The value of dynamic MRI studies in parotid tumors. | |
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MedLine Citation:
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PMID: 17502260 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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RATIONALE AND OBJECTIVES: To evaluate the ability of dynamic contrast-enhanced magnetic resonance imaging (MRI) to differentiate several tumor entities of the parotid gland in a prospective clinical trial. MATERIALS AND METHODS: A total of 112 patients with parotid tumors were examined with dynamic contrast-enhanced 1.5 T MRI. Precontrast axial T1-weighted imaging was used to select five slices for the dynamic study. Subsequently, a T1-weighted FLASH sequence was used for the dynamic contrast study (0.2 ml Gd/kg x body weight). Contrast agent application and the FLASH sequence were started simultaneously. Ten acquisitions of 10 seconds' scan time each were performed (total acquisition time 1:40 minutes). Signal intensity versus time (SIvT) curves was obtained for all tumors. After correlation of the categorized SIvT curves, these were compared with histopathology. Finally, all MRIs together with the tumor specific SIvT curves were re-read and correlated with histopathologic diagnosis. All reading sessions were done by three experienced radiologists. RESULTS: Four characteristic intensity-time curves were observed: pleomorphic adenoma showed a gradual increase in signal intensity, followed by a plateau phase on a low intensity level. Cysts showed a vacillating course at a low signal intensity level. Adenolymphomas as well as carcinomas showed a rapid increase in signal intensity followed by a plateau phase. Statistic significance was found for the time-to-peak values for adenolymphomas and pleomorphic adenomas and for the maximum peak signal intensity values for carcinomas. Together with other morphologic MRI criteria (contrast enhancement, border characteristics) and clinical features, a differentiation between adenolymphoma and carcinoma was possible. CONCLUSIONS: With additional dynamic contrast-enhanced MRI, a more reliable differentiation between common parotid tumors is possible before surgery. |
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Authors:
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Sedat Alibek; Johannes Zenk; Alessandro Bozzato; Michael Lell; Markus Grunewald; Katharina Anders; Christina Rabe; Heinrich Iro; Werner Bautz; Holger Greess |
Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Academic radiology Volume: 14 ISSN: 1076-6332 ISO Abbreviation: Acad Radiol Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-05-15 Completed Date: 2007-08-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9440159 Medline TA: Acad Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 701-10 Citation Subset: IM |
Affiliation:
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Institute of Radiology, University of Erlangen/Nuremberg, Maximiliansplatz 1 - 91054 Erlangen, Germany. sedat.alibek@idr.imed.uni-erlangen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenolymphoma
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diagnosis*,
surgery Adenoma, Pleomorphic / diagnosis*, surgery Adolescent Adult Aged Aged, 80 and over Carcinoma / diagnosis*, surgery Child Contrast Media / administration & dosage Diagnosis, Differential Female Gadolinium / diagnostic use Humans Image Enhancement / methods Magnetic Resonance Imaging / methods* Male Middle Aged Observer Variation Parotid Gland / pathology*, surgery Parotid Neoplasms / diagnosis*, surgery Predictive Value of Tests Prospective Studies Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 7440-54-2/Gadolinium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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