Document Detail

The value of defibrillator electrograms for recognition of clinical ventricular tachycardias and for pace mapping of post-infarction ventricular tachycardia.
MedLine Citation:
PMID:  20828650     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The purpose of this study was to assess the value of implantable cardioverter-defibrillator (ICD) electrograms (EGMs) in identifying clinically documented ventricular tachycardias (VTs). BACKGROUND: Twelve-lead electrocardiograms (ECG) of spontaneous VT often are not available in patients referred for catheter ablation of post-infarction VT. Many of these patients have ICDs, and the ability of ICD EGMs to identify a specific configuration of VT has not been described. METHODS: In 21 consecutive patients referred for catheter ablation of post-infarction VT, 124 VTs (mean cycle length: 393 ± 103 ms) were induced, and ICD EGMs were recorded during VT. Clinical VT had been documented with 12-lead ECGs in 15 of 21 patients. The 12-lead ECGs of the clinical VTs were compared with 64 different inducible VTs (mean cycle length: 390 ± 91 ms) to assess how well the ICD EGMs differentiated the clinical VTs from the other induced VTs. The exit site of 62 VTs (mean cycle length: 408 ± 112 ms) was identified by pace mapping (10 to 12 of 12 matching leads). The spatial resolution of pace mapping to identify a VT exit site was determined for both the 12-lead ECGs and the ICD EGMs using a customized MATLAB program (version 7.5, The MathWorks, Inc., Natick, Massachusetts). RESULTS: Analysis of stored EGMs by comparison of receiver-operating characteristic curve cutoff values accurately distinguished the clinical VTs from 98% of the other inducible VTs. The mean spatial resolution of a 12-lead ECG pace map for the VT exit site was 2.9 ± 4.0 cm(2) (range 0 to 17.5 cm(2)) compared with 8.9 ± 9.0 cm(2) (range 0 to 35 cm(2)) for ICD EGM pace maps. The spatial resolution of pace mapping varied greatly between patients and between VTs. The spatial resolution of ICD EGMs was < 1.0 cm(2) for ≥ 1 of the target VTs in 12 of 21 patients and 19 of 62 VTs. By visual inspection of the ICD EGMs, 96% of the clinical VTs were accurately differentiated from previously undocumented VTs. CONCLUSIONS: Stored ICD EGMs usually are an accurate surrogate for 12-lead ECGs for differentiating clinical VTs from other VTs. Pace mapping based on ICD EGMs has variable resolution but may be useful for identifying a VT exit site.
Kentaro Yoshida; Tzu-Yu Liu; Clayton Scott; Alfred Hero; Miki Yokokawa; Sanjaya Gupta; Eric Good; Fred Morady; Frank Bogun
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  56     ISSN:  1558-3597     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-10     Completed Date:  2010-10-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  969-79     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA.
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MeSH Terms
Body Surface Potential Mapping
Catheter Ablation
Defibrillators, Implantable*
Myocardial Infarction / complications*
ROC Curve
Tachycardia, Ventricular / diagnosis*,  surgery
Comment In:
J Am Coll Cardiol. 2010 Sep 14;56(12):980-2   [PMID:  20828651 ]

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