Document Detail


The value of customised centiles in assessing perinatal mortality risk associated with parity and maternal size.
MedLine Citation:
PMID:  19538413     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: We wanted to compare customised and population standards for defining smallness for gestational age (SGA) in the assessment of perinatal mortality risk associated with parity and maternal size. DESIGN: Population-based cohort study. SETTING: Sweden. POPULATION: Swedish Birth Registry database 1992-1995 with 354 205 complete records. METHOD: Coefficients were derived and applied to determine SGA by the fully customised method, or by adjustment for fetal sex only, and using the same fetal weight standard. MAIN OUTCOME MEASURE: Perinatal deaths and rates of small for gestational age (SGA) babies within subgroups stratified by parity, body mass index (BMI) and maternal size within the BMI range of 20.0-24.9. RESULTS: Perinatal mortality rates (PMR) had a U-shaped distribution in parity groups, increased proportionately with maternal BMI, and had no association with maternal size within the normal BMI range. For each of these subgroups, SGA rates determined by the customised method showed strong association with the PMR. In contrast, SGA based on uncustomised, population-based centiles had poor correlation with perinatal mortality. The increased perinatal mortality risk in pregnancies of obese mothers was associated with an increased risk of SGA using customised centiles, and a decreased risk of SGA using population-based centiles. CONCLUSION: The use of customised centiles to determine SGA improves the identification of pregnancies which are at increased risk of perinatal death.
Authors:
J Gardosi; B Clausson; A Francis
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Publication Detail:
Type:  Journal Article     Date:  2009-06-17
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  116     ISSN:  1471-0528     ISO Abbreviation:  BJOG     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-20     Completed Date:  2009-09-30     Revised Date:  2010-01-19    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  England    
Other Details:
Languages:  eng     Pagination:  1356-63     Citation Subset:  AIM; IM    
Affiliation:
Perinatal Institute, Birmingham, UK. jason.gardosi@pi.nhs.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Birth Weight
Body Mass Index*
Body Size / physiology*
Epidemiologic Methods
Female
Fetal Growth Retardation / mortality
Fetal Weight / physiology
Humans
Infant, Newborn
Infant, Small for Gestational Age / physiology*
Male
Parity / physiology*
Perinatal Mortality*
Pregnancy
Sex Factors
Sweden
Comments/Corrections
Comment In:
BJOG. 2010 Feb;117(3):371; author reply 371-2   [PMID:  20078592 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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