| The value of continuous 72-hour peritoneal lavage for peritonitis. | |
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MedLine Citation:
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PMID: 2929859 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Studies were performed in 120 rabbits to determine whether 72-hour peritoneal lavage is beneficial or harmful in the treatment of peritonitis. Results showed that against a high concentration fecal inoculum (90 percent mortality), peritoneal lavage containing gentamicin and clindamycin reduced mortality to 10 to 20 percent (p less than 0.05). Parenteral antibiotics alone and lavage not containing antibiotics did not decrease mortality. By contrast, against a low fecal inoculum (30 percent mortality), peritoneal lavage containing gentamicin and clindamycin did not alter mortality. However, lavage not containing antibiotics increased mortality to 70 to 80 percent (p less than 0.05). These data demonstrate that continuous peritoneal lavage may be helpful in the treatment of peritonitis provided the lavage solution contains antibiotics and may be harmful if it does not contain antibiotics. |
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Authors:
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P B Dobrin; P O'Keefe; W Tatarowicz; M Stachowski; R J Freeark |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of surgery Volume: 157 ISSN: 0002-9610 ISO Abbreviation: Am. J. Surg. Publication Date: 1989 Apr |
Date Detail:
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Created Date: 1989-05-10 Completed Date: 1989-05-10 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370473 Medline TA: Am J Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 368-71; discussion 371 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, Loyola University Medical Center, Maywood, Illinois 60153. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bacterial Infections / drug therapy, microbiology, therapy Clindamycin / administration & dosage, therapeutic use Drug Therapy, Combination / therapeutic use Gentamicins / administration & dosage, therapeutic use Male Peritoneal Lavage* Peritonitis / drug therapy, microbiology, therapy* Rabbits Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Gentamicins; 18323-44-9/Clindamycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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