Document Detail

The value of assessing myocardial deformation at recovery after dobutamine stress echocardiography.
MedLine Citation:
PMID:  25309689     Owner:  NLM     Status:  PubMed-not-MEDLINE    
BACKGROUND: The purpose of this study was to evaluate whether performing an assessment of myocardial deformation using speckle tracking imaging during the recovery period after dobutamine stress echocardiography (DSE) allows detection of significant coronary artery disease (CAD) in patients with chest discomfort.
METHODS: DSE and coronary angiography were performed in 44 patients with chest discomfort. The mean global longitudinal peak systolic strain (GLS) was measured at rest, at low stress (dobutamine infusion rate of 10 µg/kg/min) and at recovery (5 min after cessation of dobutamine infusion) of DSE using automated function imaging with apical views. Fractional flow reserve (FFR) was also performed in patients with intermediate coronary stenosis. CAD was defined as having a ≥ 70% diameter stenosis on coronary angiography or as having a FFR < 0.8. Patients were divided two groups based on the absence or presence of CAD [CAD (-) group vs. CAD (+) group].
RESULTS: There were no significant differences in the clinical characteristics and results of conventional echocardiography between the two groups. GLS at recovery was lower in the CAD (+) group than in the CAD (-) group (-18.0 ± 3.4% vs. -21.0 ± 1.9%, p = 0.003). The optimal cutoff of GLS at recovery for detection of CAD was -19% (sensitivity of 70.6%, specificity of 83.3%).
CONCLUSION: Assessment of GLS at recovery of DSE is a reliable and objective method for detection of CAD. This finding may suggest that systolic myocardial stunning remains even after recovery of wall motion abnormalities in patients with CAD.
Hui-Jeong Hwang; Hyae-Min Lee; In-Ho Yang; Jung Lok Lee; Hyun Young Pak; Chang-Bum Park; Eun-Sun Jin; Jin-Man Cho; Chong-Jin Kim; Il Suk Sohn
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Publication Detail:
Type:  Journal Article     Date:  2014-09-29
Journal Detail:
Title:  Journal of cardiovascular ultrasound     Volume:  22     ISSN:  1975-4612     ISO Abbreviation:  J Cardiovasc Ultrasound     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-10-13     Completed Date:  2014-10-13     Revised Date:  2014-10-15    
Medline Journal Info:
Nlm Unique ID:  101477138     Medline TA:  J Cardiovasc Ultrasound     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  127-33     Citation Subset:  -    
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