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The value of the Thomas-plot in the diagnostic work up of anemic patients referred by general practitioners.
MedLine Citation:
PMID:  20175793     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
In patients with inflammatory conditions, diagnosing classic iron deficiency or anemia of chronic disease is challenging. In this study, we assessed the diagnostic value of the so-called Thomas'-plot [soluble transferrin receptor (sTfR)/log ferritin (sTfr/log Ferr) and the reticulocyte hemoglobin equivalent (Ret-HE)] in the anemia work up of patients referred by general practitioners. During July 2008-March 2009, 337 consecutive patients were included because of lowered Hb values. The laboratory results of the first 133 consecutive patients were used to determine the cut-off values for the diagnostic plot. The laboratory results of these patients were assessed and interpreted independently by two investigators, blinded from sTfR/log Ferr and Ret-HE values. The following 204 patients were used to test the plot in practice. In 32% of the first 133 patients, no indication of the cause of anemia could be found. However, when using the diagnostic plot in the following 204 patients, this fraction decreased to 14%. The 'Thomas'-plot is of diagnostic value for distinguishing functional iron deficiency from classic iron deficiency in a patient population referred by general practitioners.
Authors:
M P G Leers; J F W Keuren; W P Oosterhuis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of laboratory hematology     Volume:  32     ISSN:  1751-553X     ISO Abbreviation:  Int J Lab Hematol     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-10-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101300213     Medline TA:  Int J Lab Hematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  572-81     Citation Subset:  IM    
Copyright Information:
© 2010 Blackwell Publishing Ltd.
Affiliation:
Department of Clinical Chemistry & Hematology, Atrium Medical Center Parkstad, The Netherlands. m.leers@atriummc.nl
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