Document Detail

The value of C-reactive protein measurement in the diagnosis of neonatal infection.
MedLine Citation:
PMID:  2265018     Owner:  NLM     Status:  MEDLINE    
We examined whether serum C-reactive protein (CRP) measurements used in conjunction with leucocyte counts help in the diagnosis of perinatally acquired and nosocomial infections in very preterm newborn infants. One hundred and twenty-five infants born at a gestational age between 23 and 31 weeks with respiratory distress were studied at birth. A similar group of 85 infants beyond 3 days of age were also studied on 100 occasions for suspected infection. The diagnosis of proven or probable infection was correlated with abnormal haematology (leucopenia less than 5000/mm3, leucocytosis greater than 20,000/mm3 or ratio of immature forms to total neutrophils of greater than 0.2) and an elevated CRP (greater than 10 mg/L) singly or in combination. The sensitivity of an elevated CRP was relatively higher than abnormal haematology in both early and late infections and the sensitivity was highest when either test was abnormal. Similarly, the specificity, positive and negative predictive values and efficiency of an elevated CRP was relatively higher than abnormal haematology. The performance of the tests in 45 infants born at 23-28 weeks gestation was similar to that in 80 infants born at 29-31 weeks gestation. It was concluded that both CRP and leucocyte counts should be determined as they provide valuable information in the diagnosis of neonatal bacterial infection.
K Seibert; V Y Yu; J C Doery; D Embury
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of paediatrics and child health     Volume:  26     ISSN:  1034-4810     ISO Abbreviation:  J Paediatr Child Health     Publication Date:  1990 Oct 
Date Detail:
Created Date:  1991-02-11     Completed Date:  1991-02-11     Revised Date:  2007-09-24    
Medline Journal Info:
Nlm Unique ID:  9005421     Medline TA:  J Paediatr Child Health     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  267-70     Citation Subset:  IM    
Department of Paediatrics, Monash Medical Centre, Clayton, Victoria, Australia.
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MeSH Terms
Bacterial Infections / diagnosis*
C-Reactive Protein / analysis*
Cross Infection / diagnosis
Infant, Newborn
Infant, Premature, Diseases / diagnosis*
Leukocyte Count*
Predictive Value of Tests
Sensitivity and Specificity
Reg. No./Substance:
9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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