Document Detail

The validity and reproducibility of food-frequency questionnaire-based total antioxidant capacity estimates in Swedish women.
MedLine Citation:
PMID:  18469246     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Total antioxidant capacity (TAC) provides an assessment of antioxidant activity and synergistic interactions of redox molecules in foods and plasma. OBJECTIVE: We investigated the validity and reproducibility of food-frequency questionnaire (FFQ)-based TAC estimates assessed by oxygen radical absorbance capacity (ORAC), total radical-trapping antioxidant parameters (TRAP), and ferric-reducing antioxidant power (FRAP) food values. DESIGN: Validity and reproducibility were evaluated in 2 random samples from the Swedish Mammography Cohort. Validity was studied by comparing FFQ-based TAC estimates with one measurement of plasma TAC in 108 women (54-73-y-old dietary supplement nonusers). Reproducibility was studied in 300 women (56-75 y old, 50.7% dietary supplement nonusers) who completed 2 FFQs 1 y apart. RESULTS: Fruit and vegetables (mainly apples, pears, oranges, and berries) were the major contributors to FFQ-based ORAC (56.5%), TRAP (41.7%), and FRAP (38.0%) estimates. In the validity study, whole plasma ORAC was correlated (Pearson) with FFQ-based ORAC (r = 0.35), TRAP (r = 0.31), and FRAP (r = 0.28) estimates from fruit and vegetables. Correlations between lipophilic plasma ORAC and FFQ-based ORAC, TRAP, and FRAP estimates from fruit and vegetables were 0.41, 0.31, and 0.28, and correlations with plasma TRAP estimates were 0.31, 0.30, and 0.28, respectively. Hydrophilic plasma ORAC and plasma FRAP values did not correlate with FFQ-based TAC estimates. Reproducibility, assessed by intraclass correlations, was 0.60, 0.61, and 0.61 for FFQ-based ORAC, TRAP, and FRAP estimates, respectively, from fruit and vegetables. CONCLUSIONS: FFQ-based TAC values represent valid and reproducible estimates that may be used in nutritional epidemiology to assess antioxidant intake from foods. Further studies in other populations to confirm these results are needed.
Susanne Rautiainen; Mauro Serafini; Ralf Morgenstern; Ronald L Prior; Alicja Wolk
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Validation Studies    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  87     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-12     Completed Date:  2008-06-11     Revised Date:  2009-05-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1247-53     Citation Subset:  AIM; IM    
Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
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MeSH Terms
Antioxidants / analysis*,  metabolism*
Cohort Studies
Ferric Compounds / metabolism
Fruit / metabolism*
Middle Aged
Plasma / chemistry,  metabolism
Questionnaires / standards*
Reactive Oxygen Species / metabolism
Reproducibility of Results
Sensitivity and Specificity
Vegetables / metabolism*
Reg. No./Substance:
0/Antioxidants; 0/Ferric Compounds; 0/Reactive Oxygen Species

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