| On the validity of blood flow measurement using colored microspheres. | |
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MedLine Citation:
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PMID: 10199837 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was 1) to investigate the validity of repeated estimations of blood flow using colored microspheres (CMS) and 2) to develop and validate a method that permits four consecutive estimations in the same animal using nonradiolabeled microspheres (NRMS). Several mixtures of different types of microspheres were injected in dogs, with each mixture containing the radiolabeled microspheres (RMS; labeled with 113Sn) with either three CMS, four CMS, or three CMS and one type of fluorescent (crimson labeled) microsphere (FMS). The blood flows estimated with the use of any of the injected microspheres were compared with those measured using the RMS as the "gold standard." The results were analyzed by 1) regression analysis, 2) variance analysis (ANOVA I), and 3) estimation of the limits of agreement between RMS and NRMS flow rates. The results indicate that simultaneous estimations of blood flow obtained with the use of more than three CMS lack accuracy and reliability. A combination of three types of CMS with crimson-labeled FMS, however, offers the possibility to estimate consecutively four different flow rates in the same animal in an accurate way and with relatively high precision. |
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Authors:
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D Hodeige; M de Pauw; W Eechaute; J Weyne; G R Heyndrickx |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of physiology Volume: 276 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1999 Apr |
Date Detail:
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Created Date: 1999-05-13 Completed Date: 1999-05-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H1150-8 Citation Subset: IM |
Affiliation:
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Department of Physiology, University of Gent, B-9000 Ghent, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Blood Circulation / physiology* Color Dogs Evaluation Studies as Topic Fluorescence Fluorometry Microspheres* Regression Analysis Tin Radioisotopes |
| Chemical | |
Reg. No./Substance:
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0/Tin Radioisotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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