| The validity of acid-fast smears in the diagnosis of pulmonary tuberculosis. | |
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MedLine Citation:
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PMID: 1699506 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The acid-fast smear remains an important tool in the diagnosis of tuberculosis. Some reports have questioned the validity of this stain in situations of low prevalence. We examined the relationship between prevalence and predictive value of sputum smears in one laboratory during periods of both low and high laboratory prevalence of Mycobacterium tuberculosis. Smears were examined by fluorescence and confirmed by Kinyoun stain. The number of samples positive for mycobacteria increased from 128 (4.3%) of 2956 during the 1975 through 1978 study period to 197 (8.4%) of 2347 during the 1979 through 1982 study period. Of 47 positive smears during the first study period, only one was a false-positive. None of 96 positive smears during the second period was a false-positive. The positive predictive value of acid-fast microscopy was 97.9% and 100% for the two periods examined. We have demonstrated in practice the small effect of a shift in prevalence on the positive predictive value of an acid-fast smear when specificity is maintained. |
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Authors:
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F Gordin; G Slutkin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of pathology & laboratory medicine Volume: 114 ISSN: 0003-9985 ISO Abbreviation: Arch. Pathol. Lab. Med. Publication Date: 1990 Oct |
Date Detail:
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Created Date: 1990-11-16 Completed Date: 1990-11-16 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7607091 Medline TA: Arch Pathol Lab Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1025-7 Citation Subset: AIM; IM |
Affiliation:
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Medical Service, San Francisco (Calif) General Hospital. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Humans Mycobacterium tuberculosis / isolation & purification Predictive Value of Tests Sputum / microbiology Staining and Labeling* Tuberculosis, Pulmonary / diagnosis*, microbiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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