Document Detail


A validation study of nasal spectroscopy: Rhinolux.
MedLine Citation:
PMID:  17453227     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study is the first to validate the Rhinolux against acoustic rhinometry in detecting nasal mucosal swelling when changing body position from sitting to supine. The Rhinolux (Rhios GmbH, Germany) is a new device using a light-absorption technique called nasal spectroscopy and to measure changes in nasal blood volume as a sign of nasal mucosal swelling in real time. The relationship between the changes in nasal blood volume measured with the Rhinolux and changes in nasal mucosal swelling has however, not previously been validated objectively. To evaluate this relationship we compared the Rhinolux to acoustic rhinometry following the change in body position from sitting to supine. The study population consisted of 20 healthy subjects (7 women, 13 men, mean age 34.7 +/- 9.3 years). The Rhinolux was applied sitting in the upright position followed by 5 min in the supine position. Acoustic rhinometry was measured sitting in the upright position and after 5 min in the supine position. In seven subjects the measurements were repeated on three different days to assess the repeatability. The mean change from baseline in minimal cross sectional area DeltaMCA measured with acoustic rhinometry was -0.12(+/-0.19) cm2 (right + left side), P = 0.013 but DeltaE (change in light extinction from baseline) measured with the Rhinolux was unchanged 0.02(+/-0.18) optical densities (OD), P = 0.56. There was no correlation between DeltaE and DeltaMCA r = 0.028, P = 0.9. The mean DeltaE result from repeated measurements on different days was 0.05(+/-0.08) OD, P = 0.09 and the DeltaMCA was -0.1(+/-0.11) cm2, P = 0.02. This study showed that the changes in nasal blood volume measured with the Rhinolux did not reflect changes in nasal mucosal swelling measured with acoustic rhinometry when changing body position from sitting to supine. The results indicate that the utility of the Rhinolux in assessing nasal mucosal reactions has to be evaluated further.
Authors:
Johan Hellgren; Connie Katelaris; Janet Rimmer
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Publication Detail:
Type:  Journal Article     Date:  2007-04-24
Journal Detail:
Title:  European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery     Volume:  264     ISSN:  0937-4477     ISO Abbreviation:  Eur Arch Otorhinolaryngol     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-07-26     Completed Date:  2008-04-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9002937     Medline TA:  Eur Arch Otorhinolaryngol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1009-12     Citation Subset:  IM    
Affiliation:
The Woolcock Institute of Medical Research, The Royal Prince Alfred Hospital, University of Sydney, The Page Chest Pavilion, level 7, Missenden Road, Sydney, 2006, NSW, Australia. johanh@med.usyd.edu.au
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MeSH Terms
Descriptor/Qualifier:
Acoustics
Adult
Equipment Design
Female
Humans
Light
Male
Models, Statistical
Nasal Mucosa / pathology*
Nose Diseases / diagnosis
Rhinitis / diagnosis*
Rhinomanometry / methods
Rhinometry, Acoustic / methods*
Spectrum Analysis / instrumentation*,  methods*
Supine Position

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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