Document Detail


The vagus nerve mediates behavioural depression, but not fever, in response to peripheral immune signals; a functional anatomical analysis.
MedLine Citation:
PMID:  11122354     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cytokines act on the brain to induce fever and behavioural depression after infection. Although several mechanisms of cytokine-to-brain communication have been proposed, their physiological significance is unclear. We propose that behavioural depression is mediated by the vagus nerve activating limbic structures, while fever would primarily be due to humoral mechanisms affecting the preoptic area, including interleukin-6 (IL-6) action on the organum vasculosum of the laminae terminalis (OVLT) and induction of prostaglandins. This study assessed the effects of subdiaphragmatic vagotomy in rats on fever, behavioural depression, as measured by the social interaction test, and Fos expression in the brain. These responses were compared with induction of the prostaglandin-producing enzyme cyclooxygenase-2 and the transcription factor Stat3 that translocates after binding of IL-6. Vagotomy blocked behavioural depression after intraperitoneal injection of recombinant rat IL-1beta (25 microg/kg) or lipopolysaccharide (250 microg/kg; LPS) and prevented Fos expression in limbic structures and ventromedial preoptic area, but not in the OVLT. Fever was not affected by vagotomy, but associated with translocation of Stat3 in the OVLT and cyclooxygenase-2 induction around blood vessels. These results indicate that the recently proposed vagal link between the immune system and the brain activates limbic structures to induce behavioural depression after abdominal inflammation. Although the vagus might play a role in fever in response to low doses of LPS by activating the ventromedial preoptic area, it is likely to be overridden during more severe infection by action of circulating IL-6 on the OVLT or prostaglandins induced along blood vessels of the preoptic area.
Authors:
J P Konsman; G N Luheshi; R M Bluthé; R Dantzer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The European journal of neuroscience     Volume:  12     ISSN:  0953-816X     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-02-09     Completed Date:  2001-02-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  4434-46     Citation Subset:  IM    
Affiliation:
INSERM U394, Neurobiologie Intégrative, Institut François Magendie, Rue Camille Saint-Saëns, 33077 Bordeaux Cedex, France. jpkonsman@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Temperature / drug effects,  physiology
Brain / drug effects,  physiology*,  physiopathology
Cyclooxygenase 2
Escherichia coli
Fever / physiopathology*,  prevention & control
Gene Expression Regulation / drug effects
Genes, fos
Interleukin-1 / pharmacology*
Interleukin-6 / pharmacology*
Isoenzymes / metabolism
Limbic System / drug effects,  physiology*
Lipopolysaccharides / toxicity
Male
Preoptic Area / drug effects,  physiology
Prostaglandin-Endoperoxide Synthases / metabolism
Rats
Rats, Wistar
Recombinant Proteins / pharmacology
Social Behavior*
Vagotomy
Vagus Nerve / physiology*
Chemical
Reg. No./Substance:
0/Interleukin-1; 0/Interleukin-6; 0/Isoenzymes; 0/Lipopolysaccharides; 0/Recombinant Proteins; EC 1.14.99.1/Cyclooxygenase 2; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases

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