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A vaccine for hypertension based on peptide AngI-R: A pilot study.
MedLine Citation:
PMID:  19932924     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
AIMS: We aim to modulate the renin-angiotensin system (RAS) by active immunization against angiotensin I/II, potentially by a novel type of peptide-'AngI-R' for the treatment of hypertension.
METHOD: 27 spontaneous hypertensive rats (SHRs) were randomly divided into 3 groups (n=9). Effect of AngI-R on systolic blood pressure of SHRs was determined by its subcutaneous injection into SHRs with anti-angiotensin peptide AngI-R, captopril, physiological salt solution in the same schedule. Systolic blood pressure was monitored by tail-cuff arterial blood pressure measurement method and then calculated from the average of three measurements in each animal at a desired time (0, 4, 8, 16W). AngI, AngII and anti-AngI antibody were detected by ELISA and western blotting method. At the end, the pathologic changes in different organs of SHRs were observed.
RESULT: The results exhibited a marked effect to lower the systolic blood pressure (-15mm Hg) of SHRs after subcutaneous injection with peptide AngI-R. The anti-hypertensive effect lasted for over 1month. The level of AngI and AngII in the vaccinated group, after administration of AngI-R was lower than the one in the control group and the pre-administered group. The anti-AngI/II antibody titre in the experiment group significantly increased.
CONCLUSION: The peptide AngI-R was able to decrease the blood pressure of SHRs. The peptide AngI-R induced an immune response to inhibit AngI and AngII, resulting in the decrease in blood pressure in SHRs.
Authors:
Fang Hong; Wu Yong Quan; Rabindra Pandey; Shen Yi; Liu Chi; Li Zhan Xia; Ma Yuan; Lou Ming
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Publication Detail:
Type:  Journal Article     Date:  2009-11-24
Journal Detail:
Title:  International journal of cardiology     Volume:  148     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  76-84     Citation Subset:  IM    
Copyright Information:
Copyright © 2009 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Department of Cardiology, Tongji Hospital Affiliated to Tongji University, Shanghai 200065, China.
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