| A vaccine for hypertension based on peptide AngI-R: A pilot study. | |
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MedLine Citation:
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PMID: 19932924 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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AIMS: We aim to modulate the renin-angiotensin system (RAS) by active immunization against angiotensin I/II, potentially by a novel type of peptide-'AngI-R' for the treatment of hypertension. METHOD: 27 spontaneous hypertensive rats (SHRs) were randomly divided into 3 groups (n=9). Effect of AngI-R on systolic blood pressure of SHRs was determined by its subcutaneous injection into SHRs with anti-angiotensin peptide AngI-R, captopril, physiological salt solution in the same schedule. Systolic blood pressure was monitored by tail-cuff arterial blood pressure measurement method and then calculated from the average of three measurements in each animal at a desired time (0, 4, 8, 16W). AngI, AngII and anti-AngI antibody were detected by ELISA and western blotting method. At the end, the pathologic changes in different organs of SHRs were observed. RESULT: The results exhibited a marked effect to lower the systolic blood pressure (-15mm Hg) of SHRs after subcutaneous injection with peptide AngI-R. The anti-hypertensive effect lasted for over 1month. The level of AngI and AngII in the vaccinated group, after administration of AngI-R was lower than the one in the control group and the pre-administered group. The anti-AngI/II antibody titre in the experiment group significantly increased. CONCLUSION: The peptide AngI-R was able to decrease the blood pressure of SHRs. The peptide AngI-R induced an immune response to inhibit AngI and AngII, resulting in the decrease in blood pressure in SHRs. |
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Authors:
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Fang Hong; Wu Yong Quan; Rabindra Pandey; Shen Yi; Liu Chi; Li Zhan Xia; Ma Yuan; Lou Ming |
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Publication Detail:
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Type: Journal Article Date: 2009-11-24 |
Journal Detail:
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Title: International journal of cardiology Volume: 148 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 76-84 Citation Subset: IM |
Copyright Information:
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Copyright © 2009 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Cardiology, Tongji Hospital Affiliated to Tongji University, Shanghai 200065, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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