Document Detail

v-Myb suppresses phorbol ester- and modifies retinoic acid-induced differentiation of human promonocytic U937 cells.
MedLine Citation:
PMID:  18505338     Owner:  NLM     Status:  MEDLINE    
The c-myb protooncogene as well as its transforming derivate, the v-myb oncogene code for transcription factors. They regulate transcription of specific target genes thus controlling proliferation, differentiation and apoptosis of hematopoietic cells. Up-regulation of the c-myb expression or rearrangement/amplification of the myb locus are often involved in leukemogenesis. Enforced myb expression blocks differentiation of various leukemic cell lines. Human promonocytes U937 can be induced to differentiate to monocyte/macrophage-like cells using phorbol esters or to granulocytes using retinoic acid. In order to investigate transforming capability of v-myb, we expressed the v-myb oncogene of avian myeloblastosis virus in U937 cells. We found that v-Myb efficiently suppressed formation of macrophages upon treatment with phorbol ester. Some features of granulocytic differentiation of retinoic acid-treated U937 cells were affected by the v-Myb protein as well. These results document that v-Myb is significantly involved in control of myeloid differentiation.
L Knopfova; J Smarda
Related Documents :
10678368 - Tetracycline-induced expression of an anti-c-myb single-chain antibody and its inhibito...
1992438 - Two c-myb proteins differing by their aminotermini exhibit different transcriptional tr...
23372488 - Renewing the assault on mrna.
23357978 - Synergistic activity of bortezomib and hdacis in preclinical models of b-cell precursor...
19237298 - Altered regulation of aquaporin gene expression in allergen and il-13-induced mouse mod...
19837168 - Fragile x mental retardation protein control of neuronal mrna metabolism: insights into...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neoplasma     Volume:  55     ISSN:  0028-2685     ISO Abbreviation:  Neoplasma     Publication Date:  2008  
Date Detail:
Created Date:  2008-05-28     Completed Date:  2008-08-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0377266     Medline TA:  Neoplasma     Country:  Slovakia    
Other Details:
Languages:  eng     Pagination:  286-93     Citation Subset:  IM    
Institute of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cell Differentiation / drug effects*
Cell Transformation, Viral
Gene Expression
Genes, myb*
Granulocytes / drug effects
Macrophages / drug effects*
Monocytes / drug effects*
Phorbol Esters / pharmacology*
Tretinoin / pharmacology*
U937 Cells
Reg. No./Substance:
0/Phorbol Esters; 302-79-4/Tretinoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Reduction of genotoxic effects of N-nitrosomorpholine in human hepatoma cells and hamster lung cells...
Next Document:  Influence of chemotherapy to hormonal levels in postmenopausal breast cancer patients.