Document Detail


v-Myb suppresses phorbol ester- and modifies retinoic acid-induced differentiation of human promonocytic U937 cells.
MedLine Citation:
PMID:  18505338     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The c-myb protooncogene as well as its transforming derivate, the v-myb oncogene code for transcription factors. They regulate transcription of specific target genes thus controlling proliferation, differentiation and apoptosis of hematopoietic cells. Up-regulation of the c-myb expression or rearrangement/amplification of the myb locus are often involved in leukemogenesis. Enforced myb expression blocks differentiation of various leukemic cell lines. Human promonocytes U937 can be induced to differentiate to monocyte/macrophage-like cells using phorbol esters or to granulocytes using retinoic acid. In order to investigate transforming capability of v-myb, we expressed the v-myb oncogene of avian myeloblastosis virus in U937 cells. We found that v-Myb efficiently suppressed formation of macrophages upon treatment with phorbol ester. Some features of granulocytic differentiation of retinoic acid-treated U937 cells were affected by the v-Myb protein as well. These results document that v-Myb is significantly involved in control of myeloid differentiation.
Authors:
L Knopfova; J Smarda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neoplasma     Volume:  55     ISSN:  0028-2685     ISO Abbreviation:  Neoplasma     Publication Date:  2008  
Date Detail:
Created Date:  2008-05-28     Completed Date:  2008-08-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0377266     Medline TA:  Neoplasma     Country:  Slovakia    
Other Details:
Languages:  eng     Pagination:  286-93     Citation Subset:  IM    
Affiliation:
Institute of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic.
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MeSH Terms
Descriptor/Qualifier:
Cell Differentiation / drug effects*
Cell Transformation, Viral
Gene Expression
Genes, myb*
Granulocytes / drug effects
Humans
Macrophages / drug effects*
Monocytes / drug effects*
Phorbol Esters / pharmacology*
Transfection
Tretinoin / pharmacology*
U937 Cells
Chemical
Reg. No./Substance:
0/Phorbol Esters; 302-79-4/Tretinoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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