Document Detail


The utilization of circulating cell-free fetal DNA testing and decrease in invasive diagnostic procedures: an institutional experience.
MedLine Citation:
PMID:  24875410     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective:To characterize the patient population utilizing circulating cell-free fetal DNA (ccffDNA) testing at a large academic center and evaluate trends in the performance of invasive diagnostic procedures.Study design:A retrospective cohort study of all patients who underwent cell-free DNA testing from May to December 2012 was performed.Result:During the study period, 206 patients had cell-free DNA testing. Of those, 75% (155/206) were of ages ⩾35 years. Of those undergoing ccffDNA testing, 41% had positive aneuploidy screening and 38% had abnormal ultrasound findings. Only 7% of the patients with negative ccffDNA testing opted for an invasive diagnostic procedure compared with 60% with positive testing (P<0.01). The rate of invasive procedures decreased from 5.9% of all visits to the center during a similar 8-month period in 2010 to 4.1% of all visits during the study period (P<0.01).Conclusion:Our data suggest that ccffDNA testing leads to reduced uptake of invasive procedures.Journal of Perinatology advance online publication, 29 May 2014; doi:10.1038/jp.2014.102.
Authors:
K E Pettit; A D Hull; L Korty; M C Jones; D H Pretorius
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-5-29
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  -     ISSN:  1476-5543     ISO Abbreviation:  J Perinatol     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-5-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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