| The utility of two somatostatin analog radiopharmaceuticals in assessment of radiologically indeterminate pulmonary lesions. | |
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MedLine Citation:
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PMID: 22157022 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE: : The aim of our study was to assess diagnostic accuracy of Tc-99m depreotide and Tc-99m-EDDA/HYNIC-TOC scintigraphy for evaluation of pulmonary lesions that appeared ambiguous on computed tomography (CT). MATERIAL AND METHODS: : Forty-nine consecutive patients (37 men and 12 women; mean age, 60 ± 11 years) with 60 pulmonary lesions on chest radiography and CT were referred for nuclear imaging. They were prospectively allocated to undergo whole-body scintigraphy (WBS) and single photon emission computed tomography (SPECT) using either Tc-99m depreotide (26 patients, group 1) or Tc-99m-EDDA/HYNIC-TOC imaging (23 patients, group 2). Histologic findings after tissue biopsy served as a gold standard for determining diagnostic accuracy of the 2 somatostatin analogs. Visual assessment was complemented by semiquantitative analysis based on target to background ratio. RESULTS: : Among the 32 pulmonary lesions scanned with Tc-99m depreotide, focal uptake was increased in 22 of 25 malignancies, whereas no uptake was found in 6 of 7 benign lesions (88% sensitivity, 85% specificity, and 88% accuracy) on both WBS and SPECT. Imaging of 28 pulmonary lesions with Tc-99m-EDDA/HYNIC-TOC had a similar diagnostic yield (sensitivity 87%, specificity 84%, and accuracy 86%). Overall, target to background ratios were higher on SPECT than WBS but not significantly different between groups 1 and 2 (SPECT 2.72 ± 0.70 vs. 2.71 ± 0.50, WBS 1.61 ± 0.32 vs. 1.62 ± 0.28, respectively). CONCLUSION: : This study demonstrates that Tc-99m depreotide and Tc-99m-EDDA/HYNIC-TOC have similar diagnostic value for characterizing pulmonary lesions that appear ambiguous on CT. |
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Authors:
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Dragana P Sobic-Saranovic; Smiljana V Pavlovic; Vera M Artiko; Djordjije Z Saranovic; Emilija D Jaksic; Dragan Subotic; Ljudmila Nagorni-Obradovic; Nebojsa Kozarevic; Nebojsa Petrovic; Isidora T Grozdic; Vladimir B Obradovic |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical nuclear medicine Volume: 37 ISSN: 1536-0229 ISO Abbreviation: Clin Nucl Med Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7611109 Medline TA: Clin Nucl Med Country: United States |
Other Details:
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Languages: eng Pagination: 14-20 Citation Subset: IM |
Affiliation:
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From the *Faculty of Medicine, University of Belgrade, Serbia; †Center of Nuclear Medicine, CCS, Belgrade, Serbia; ‡Center of Radiology and Magnetic Resonance Imaging, CCS, Belgrade, Serbia; and §Clinic of Pulmonary and Thoracic Surgery, CCS, Belgrade, Serbia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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