| The utility of structural biology in drug discovery. | |
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MedLine Citation:
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PMID: 22222446 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Access to detailed three-dimensional structural information on protein drug targets can streamline many aspects of drug discovery, from target selection and target product profile determination, to the discovery of novel molecular scaffolds that form the basis of potential drugs, to lead optimization. The information content of X-ray crystal structures, as well as the utility of structural methods in supporting the different phases of the drug discovery process, are described in this chapter. |
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Authors:
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Leslie W Tari |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Methods in molecular biology (Clifton, N.J.) Volume: 841 ISSN: 1940-6029 ISO Abbreviation: Methods Mol. Biol. Publication Date: 2012 |
Date Detail:
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Created Date: 2012-01-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9214969 Medline TA: Methods Mol Biol Country: United States |
Other Details:
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Languages: eng Pagination: 1-27 Citation Subset: IM |
Affiliation:
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Trius Therapeutics, San Diego, CA, USA, ltari@triusrx.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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