Document Detail


The utility of positron emission tomography/computed tomography in the staging of extranodal natural killer/T-cell lymphoma.
MedLine Citation:
PMID:  21557776     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
NK/T-cell lymphoma cases are rarely discovered using positron emission tomography/computed tomography (PET/CT). We compared the utility of PET/CT and conventional methods (CMs; CT with IV contrast, biopsies from primary sites, and bone marrow examinations) in the staging of extranodal NK/T-cell lymphoma. Nineteen untreated patients with extranodal NK/T-cell lymphoma at three institutions were analyzed. PET/CT and CMs were applied for initial workups following diagnosis. PET/CT and CMs were compared and evaluated for their ability to detect tumor lesions and their influence in the staging and treatment strategies. In total, 116 lesions were detected by CM and PET/CT. Using PET/CT, 108 lesions (93%) were discovered. The number of nodal lesions was 28: all were positive by PET/CT and 26 (93%) by CMs. The number of extranodal lesions was 89: 84 (94%) and 54 (61%) lesions were positive by PET/CT and CMs, respectively. PET/CT was superior to CMs in detecting cutaneous lesions [31/31 lesions (100%) vs. 20/31 lesions (65%), respectively; P = 0.042]. Bone marrow involvement was confirmed pathologically in only seven patients; four cases (57%) were positive by PET/CT. Using CMs, 10 patients (53%) were stage I-II and 9 (47%) were stage III-IV. Using PET/CT, 8 patients (42%) were in stage I-II and 11 (58%) were in stage III-IV. PET/CT findings altered the stage and treatment strategy in two cases (11%). Our study demonstrated that PET/CT is a useful tool for detecting extranodal lesions.in NK/T-cell lymphoma, particularly cutaneous lesions. PET/CTmay therefore influence future staging and treatment strategies.
Authors:
Hideaki Fujiwara; Yoshinobu Maeda; Yuichiro Nawa; Masayuki Yamakura; Daisuke Ennishi; Yukihiro Miyazaki; Katsuji Shinagawa; Masamichi Hara; Kosei Matsue; Mitsune Tanimoto
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-9
Journal Detail:
Title:  European journal of haematology     Volume:  -     ISSN:  1600-0609     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703985     Medline TA:  Eur J Haematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 John Wiley & Sons A/S.
Affiliation:
Division of Hematology/Oncology, Department of Medicine, Kameda General Hospital, Chiba, Japan Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate school of Medicine and Dentistry, Okayama, Japan Division of Hematology/Oncology, Department of Medicine, Ehime Prefectural Central Hospital, Ehime, Japan.
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