| The utility of p53 immunostaining of transbronchial biopsy specimens of lung cancer: p53 overexpression predicts poor prognosis and chemoresistance in advanced non-small cell lung cancer. | |
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MedLine Citation:
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PMID: 9815799 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There are few reports on the p53 status of small cell lung cancer (SCLC) and advanced non-SCLC (NSCLC) because surgically resected specimens are generally not available. Therefore, we evaluated p53 immunostaining in 175 transbronchial biopsy (TBB) specimens obtained from patients with all stages of lung cancer and retrospectively evaluated the relationship between p53 status and clinical parameters. All of the specimens were obtained prior to therapy. Formalin-fixed, paraffin-embedded TBB specimens were immunostained using an anti-p53 antibody (DO-1). p53 protein was detected in 55% (61 of 111) of NSCLCs and 58% (37 of 64) of SCLCs. The rate of positivity increased significantly with increasing stage (stages I and II, 45%; stage III, 54%; stage IV, 66%), but not with other clinical parameters. Ninety-five patients were evaluated for their response to chemotherapy. Positive staining for p53 correlated significantly with unresponsiveness to chemotherapy in NSCLC (response rate of 13 versus 60%; P = 0.006), but not in SCLC (80 versus 57%; P = 0.22). p53 positivity was a statistically significant negative prognostic factor for stage III and stage IV NSCLC (P = 0.02), but not for stage I and stage II NSCLC (P = 0.79). There was no survival difference relative to p53 status in SCLC (P = 0.35). These results indicate that p53 overexpression in TBB specimens predicts poor prognosis and chemoresistance in advanced stage NSCLC. |
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Authors:
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M Kawasaki; Y Nakanishi; K Kuwano; J Yatsunami; K Takayama; N Hara |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical cancer research : an official journal of the American Association for Cancer Research Volume: 3 ISSN: 1078-0432 ISO Abbreviation: Clin. Cancer Res. Publication Date: 1997 Jul |
Date Detail:
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Created Date: 1999-02-25 Completed Date: 1999-02-25 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9502500 Medline TA: Clin Cancer Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1195-200 Citation Subset: IM |
Affiliation:
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Research Institute for Diseases of the Chest, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antineoplastic Agents / therapeutic use* Biopsy / methods Bronchi Carcinoma, Non-Small-Cell Lung / genetics, mortality, pathology*, therapy Carcinoma, Small Cell / genetics, mortality, pathology*, therapy Female Genes, p53* Humans Immunohistochemistry Lung Neoplasms / genetics, mortality, pathology*, therapy Male Middle Aged Neoplasm Staging Prognosis Survival Analysis Tumor Suppressor Protein p53 / analysis*, genetics |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Tumor Suppressor Protein p53 |
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