Document Detail

The utility of fully automated real-time three-dimensional echocardiography in the evaluation of left ventricular diastolic function.
MedLine Citation:
PMID:  25242299     Owner:  NLM     Status:  Publisher    
BACKGROUND: A novel real-time three-dimensional echocardiography (RT3DE) system allows fully automated quantification of the left ventricular (LV) volume throughout a cardiac cycle. This study aimed to investigate whether an LV time-volume curve, obtained using fully automated RT3DE, is useful in the evaluation of LV diastolic function.
METHODS: First, 15 patients underwent simultaneous standard two-dimensional echocardiography (2DE), RT3DE, and cardiac catheterization to measure the time constant of the isovolumic-pressure decline (τ). From the LV time-volume curve obtained using RT3DE, peak early filling rate (PFR) during diastole was generated and indexed for LV end-systolic volume. Next 570 patients, who were scheduled for both 2DE and RT3DE examinations, were enrolled to investigate the association between PFR index and 2DE-evidenced diastolic dysfunction and clinical characteristics.
RESULTS: Of the 585 patients, RT3DE analysis was adequate in 542 patients (feasibility 93%). In the 15 patients, PFR index showed significant correlation with τ (r=-0.65, p=0.009). In the remaining 527 patients, PFR index was related to age (r=-0.24, p<0.001) and e' (r=0.41, p<0.001). PFR index decreased in proportion to the grade of 2DE-evidenced diastolic dysfunction. All patients with normal diastolic function had a PFR index greater than 2.0.
CONCLUSIONS: This study demonstrated that a novel, fully automated RT3DE-derived PFR index was the diagnostic tool of choice for the assessment of LV diastolic function.
Koki Nakanishi; Shota Fukuda; Hiroyuki Watanabe; Yoshihiro Seo; Keitaro Mahara; Eiichi Hyodo; Kenichiro Otsuka; Tomoko Ishizu; Kenei Shimada; Tetsuya Sumiyoshi; Kazutaka Aonuma; Hitonobu Tomoike; Junichi Yoshikawa
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-18
Journal Detail:
Title:  Journal of cardiology     Volume:  -     ISSN:  1876-4738     ISO Abbreviation:  J Cardiol     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804703     Medline TA:  J Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier Ltd.
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