Document Detail

The utility of diffusion-weighted MR imaging in cervical cancer.
MedLine Citation:
PMID:  19442466     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigate the value of diffusion-weighted MR imaging (DWI) in detection of cervical cancer, and to determine the diagnostic accuracy of apparent diffusion coefficient (ADC) values for evaluating cervical cancer before and after chemoradiotherapy.
MATERIALS AND METHODS: Thirty-three patients with cervical squamous carcinoma and 20 patients with other pelvic abnormalities underwent diffusion-weighted imaging (DWI) in addition to routine MR imaging. The ADC values of normal cervical tissue, cervical area before and after chemoradiotherapy were measured and compared. Receiver operating characteristic (ROC) analysis was employed to investigate whether ADC values could help in discrimination among normal cervical tissue, cervical cancer before and after therapy, and to obtain the optimal ADC threshold value.
RESULTS: Cervical cancer lesion demonstrated obviously hyperintensity on DWI images. The mean ADC value of cervical carcinoma (1.110+/-0.175 x 10(-3)mm(2)/s) was significantly lower than that of normal cervical tissue (1.593+/-0.151 x 10(-3)mm(2)/s) (P<0.001). The mean ADC value of the cervical area in 22 patients treated by chemoradiotherapy (1.436+/-0.129 x 10(-3)mm(2)/s) was significantly higher than that before therapy (1.013+/-0.094 x 10(-3)mm(2)/s) (P<0.001). The difference of ADC values between normal cervical tissue and cervical area after therapy was statistically significant (P<0.01). The optimal ADC threshold values for distinguishing between normal cervical tissue and cervical carcinoma was 1.359 x 10(-3)mm(2)/s, between cervical area before and after therapy was 1.255 x 10(-3)mm(2)/s, between normal cervical tissue and cervical area after therapy was 1.525 x 10(-3)mm(2)/s. The sensitivity and specificity were 100% and 84.8%, 95.5% and 100%, 70% and 81.8%, respectively.
CONCLUSION: DWI can be applied for the detection of cervical cancer because of its superior disease contrast with normal tissue. The measurement of the ADC values can be a useful tool to monitor the response to therapy for cervical carcinoma.
Jianyu Chen; Yun Zhang; Biling Liang; Zehong Yang
Related Documents :
19078456 - Cranioventral subluxation of the odontoid process with accompanying neo(pseudo)arthrosi...
18442696 - Arthroscopic anterior diskectomy of the cervical spine.
18520926 - Thoracic ligament ossification in patients with cervical ossification of the posterior ...
791576 - Transverse axial tomography of the spine.
19288816 - Utility of positron emission tomography in the mediastinum: moving beyond lung and esop...
23367046 - Optimal cutoff threshold for calcium quantification in isotropic ct calcium scans by va...
Publication Detail:
Type:  Journal Article     Date:  2009-05-13
Journal Detail:
Title:  European journal of radiology     Volume:  74     ISSN:  1872-7727     ISO Abbreviation:  Eur J Radiol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-08-05     Completed Date:  2011-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106411     Medline TA:  Eur J Radiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  e101-6     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
Department of Radiology, The Second Affiliated Hospital, Sun Yat-sen University, 107 Yanjiangxi Road, Guangzhou 510120, PR China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Diffusion Magnetic Resonance Imaging / methods*
Middle Aged
Reproducibility of Results
Sensitivity and Specificity
Treatment Outcome
Uterine Cervical Neoplasms / diagnosis*,  therapy*
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Hospital LOS, medical complexity and deprivation indicators.
Next Document:  Effect of cardiac function on aortic peak time and peak enhancement during coronary CT angiography.