Document Detail

The utility of cardiopulmonary exercise testing to detect and track early-stage ischemic heart disease.
MedLine Citation:
PMID:  20884826     Owner:  NLM     Status:  MEDLINE    
Evidence demonstrating the potential value of noninvasive cardiopulmonary exercise testing (CPET) to accurately detect exercise-induced myocardial ischemia is emerging. This case-based concept report describes CPET abnormalities in an asymptomatic at-risk man with suspected early-stage ischemic heart disease. When CPET was repeated 1 year after baseline assessment, his cardiovascular function had worsened, and an anti-atherosclerotic regimen was initiated. When the patient was retested after 3.3 years, the diminished left ventricular function had reversed with pharmacotherapy directed at decreasing cardiovascular events in patients with coronary artery disease. Thus, in addition to identifying appropriate patients in need of escalating therapy for atherosclerosis, CPET was useful in monitoring progression and reversal of abnormalities of the coronary circulation in a safe and cost-effective manner without the use of radiation. Serial CPET parameters may be useful to track changes marking the progression and/or regression of the underlying global ischemic burden.
Sundeep Chaudhry; Ross A Arena; James E Hansen; Gregory D Lewis; Jonathan N Myers; Laurence S Sperling; Brian D Labudde; Karlman Wasserman
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Mayo Clinic proceedings     Volume:  85     ISSN:  1942-5546     ISO Abbreviation:  Mayo Clin. Proc.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-04     Completed Date:  2010-10-26     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  0405543     Medline TA:  Mayo Clin Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  928-32     Citation Subset:  AIM; IM    
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MeSH Terms
Anaerobic Threshold / physiology*
Cholesterol, LDL / blood
Disease Progression
Exercise Test / methods,  utilization*
Follow-Up Studies
Heart Rate
Myocardial Ischemia / blood,  diagnosis*,  physiopathology
Oxygen Consumption / physiology
Reproducibility of Results
Reg. No./Substance:
0/Cholesterol, LDL
Erratum In:
Mayo Clin Proc. 2010 Nov;85(11):1061

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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