Document Detail

The utility of cardiopulmonary exercise testing in the assessment of suspected microvascular ischemia.
MedLine Citation:
PMID:  19233492     Owner:  NLM     Status:  MEDLINE    
Evidence demonstrating the potential value of cardiopulmonary exercise testing (CPET) to accurately detect myocardial ischemia secondary to macro-vascular disease is beginning to emerge. Despite distinct mechanisms mediating ischemia in micro-vascular and macrovascular coronary artery disease (CAD), the net physiologic effect of exercise-induced left ventricular (LV) dysfunction is common to both. The abnormal physiologic response to CPET may, therefore, be similar in patients with macro- and micro-vascular ischemia. The following case report describes the CPET abnormalities in a patient with suspected microvascular CAD and the subsequent improvement in LV function following three weeks of medical therapy with the anti-ischemic drug ranolazine.
Sundeep Chaudhry; Ross Arena; Karlman Wasserman; James E Hansen; Gregory D Lewis; Jonathan Myers; Romualdo Belardinelli; Brian LaBudde; Nicholas Menasco; William E Boden
Publication Detail:
Type:  Case Reports; Letter     Date:  2009-02-23
Journal Detail:
Title:  International journal of cardiology     Volume:  148     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-22     Completed Date:  2012-02-14     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  e7-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2009 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Exercise Test / methods,  utilization*
Heart Rate / physiology
Microcirculation / physiology*
Middle Aged
Myocardial Ischemia / diagnosis*,  physiopathology*
Grant Support
K23 HL091106/HL/NHLBI NIH HHS; K23 HL091106-01A1/HL/NHLBI NIH HHS; K23 HL091106-04/HL/NHLBI NIH HHS

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