| The utility of the Sysmex XE-2100 analyzer's NEUT-X and NEUT-Y parameters for detecting neutrophil dysplasia in myelodysplastic syndromes. | |
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MedLine Citation:
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PMID: 19906272 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The diagnosis of myelodysplastic syndromes (MDS) is based on morphological changes in the blood and bone marrow. The parameters NEUT-X and NEUT-Y of the Sysmex XE-2100 analyzer could help detect neutrophil dysplasia. A control group of 50 patients, along with 50 postpartum patients, 50 anemias, 50 leukopenias, 50 patients with microscopically visible hypergranulated neutrophils and 50 MDS patients were assessed. The NEUT-X and NEUT-Y values (mean +/- SD) for the control group were 1346 +/- 28.2 and 420 +/- 19.3, respectively, with the anemia and leukopenia groups giving similar values. The postpartum and hypergranulated neutrophils groups presented higher values (P < 0.05), whereas the values in the MDS group were 1286 +/- 72.8 and 385 +/- 50.9 (P < 0.05), respectively. There were no differences between the morphological MDS types. The NEUT-X and NEUT-Y values in MDS patients with optical hypogranulation were significantly lower than for MDS patients without optical hypogranulation. NEUT-X and NEUT-Y values lower than 1298 and 398, respectively, would have a specificity for detecting MDS of 94% and 91% and would detect 60% and 56% of cases, respectively, whereas they would detect 75% and 74%, respectively, of MDS cases with optical hypogranulation. NEUT-X and NEUT-Y parameters can be used to detect neutrophil dysplasia arising from MDS and chronic myelomonocytic leukemia. |
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Authors:
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J R Furundarena; M Araiz; M Uranga; M R Sainz; A Agirre; M Trassorras; N Uresandi; M C Montes; N Argoitia |
Publication Detail:
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Type: Journal Article Date: 2009-11-10 |
Journal Detail:
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Title: International journal of laboratory hematology Volume: 32 ISSN: 1751-553X ISO Abbreviation: Int J Lab Hematol Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-11 Completed Date: 2010-09-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101300213 Medline TA: Int J Lab Hematol Country: England |
Other Details:
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Languages: eng Pagination: 360-6 Citation Subset: IM |
Affiliation:
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Hematology Laboratory, Donostia Hospital, Donostia, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anemia
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diagnosis Female Granulocytes / chemistry, cytology Humans Leukopenia / diagnosis Male Myelodysplastic Syndromes / diagnosis* Neutrophils / cytology*, pathology* ROC Curve Reference Standards Sensitivity and Specificity |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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