| The utility of Mood Disorder Questionnaire for the detection of bipolar diathesis in treatment-resistant depression. | |
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MedLine Citation:
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PMID: 20060173 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Treatment-resistant depression is a heterogeneous entity. There are many variables associated with poor response to antidepressants, one of which is missed bipolarity. Therefore, the present study investigated the bipolar diathesis between patients with treatment-resistant (TR) depression and non-treatment-resistant (NTR) depression as assessed with the Mood Disorder Questionnaire (MDQ). METHOD: The population studied included 1051 patients diagnosed with single or recurrent major depressive disorder. They were classified into a non-treatment-resistant group (481 patients) and a treatment-resistant group (570 patients). The psychiatrist, using information from the patient's medical history, psychiatric examination and available documentation, assessed each eligible patient. The symptoms of bipolarity were additionally assessed by the Mood Disorder Questionnaire. RESULTS: A positive screen on the MDQ defined as endorsement of at least 6 of the 13 yes or no questions was an independent risk factor for treatment resistance.The total MDQ score was significantly higher in TR vs NTR (4.33 vs 2.66 points p<0.001) and the percentage of patients screened positive was significantly higher in TR than in NTR (13.7% vs 5.6% p<0.001). Factor analysis resulted in 2 factors with eigenvalues >1 explaining 91.5% of total variance. CONCLUSIONS: Using the MDQ scale we confirmed the association between bipolarity and worse response to antidepressant drugs in patients with major depressive disorder. |
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Authors:
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Andrzej Kiejna; Tomasz Pawłowski; Dominika Dudek; Dorota Lojko; Marcin Siwek; Robert Roczeń; Janusz K Rybakowski |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Date: 2010-01-13 |
Journal Detail:
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Title: Journal of affective disorders Volume: 124 ISSN: 1573-2517 ISO Abbreviation: J Affect Disord Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-12 Completed Date: 2010-10-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7906073 Medline TA: J Affect Disord Country: Netherlands |
Other Details:
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Languages: eng Pagination: 270-4 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Psychiatry, Medical University of Wroclaw, Wroclaw, Poland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antidepressive Agents / therapeutic use* Bipolar Disorder / diagnosis*, psychology Depressive Disorder, Major / diagnosis*, drug therapy*, psychology Diagnosis, Differential Drug Resistance* Female Humans Male Middle Aged Poland Psychometrics / statistics & numerical data Recurrence Reproducibility of Results Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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