Document Detail

The utility of MIB-1/Ki-67 immunostaining in the evaluation of central nervous system neoplasms.
MedLine Citation:
PMID:  15900115     Owner:  NLM     Status:  MEDLINE    
The diagnosis and assignment of grade in neoplasms of the central nervous system (CNS), for the most part, are morphologically based and predicated on the interpretation of descriptions of what the phenotypic findings are for a particular tumor type. Not surprisingly, the application of various grading systems in CNS neoplasia has been limited somewhat by interobserver variability. Since assignment of grade and tumor type is the basis upon which therapeutic intervention is grounded, investigators have been searching for ancillary means by which morphologically based systems can be improved. Utilization of cell proliferation markers in the evaluation of tumors can be potentially useful in this endeavor. This review focuses on issues surrounding the utilization of MIB-1 or Ki-67 antibody in the evaluation of CNS neoplasms.
Richard A Prayson
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Advances in anatomic pathology     Volume:  12     ISSN:  1072-4109     ISO Abbreviation:  Adv Anat Pathol     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-05-18     Completed Date:  2005-08-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9435676     Medline TA:  Adv Anat Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  144-8     Citation Subset:  IM    
Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
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MeSH Terms
Antibodies, Antinuclear / analysis*
Antibodies, Monoclonal / analysis*
Astrocytoma / immunology,  pathology
Central Nervous System Neoplasms / immunology,  pathology*
Glioma / immunology,  pathology
Gliosis / immunology,  pathology
Ki-67 Antigen / analysis*
Meningioma / pathology
Staining and Labeling
Reg. No./Substance:
0/Antibodies, Antinuclear; 0/Antibodies, Monoclonal; 0/Ki-67 Antigen; 0/MIB-1 antibody

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