| The usefulness of reflectance spectrophotometric measurements during psoralens and ultraviolet A therapy for psoriasis. | |
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MedLine Citation:
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PMID: 6630617 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Reflectance spectrophotometry was used to obtain indices of the hemoglobin and melanin content of psoriatic lesions and adjacent clinically normal skin in thirteen patients undergoing photochemotherapy. The pretreatment lesional hemoglobin index was 2.8 times greater than that of adjacent uninvolved skin. With therapy, this index decreased rapidly initially, and during the second or third week approached that of the uninvolved skin. The ratio of lesional and uninvolved skin hemoglobin indices decreased to approximately 1.3, and continuation of PUVA treatment failed to reduce it further. Termination of treatment at this stage, which occurs before clinical resolution, resulted in subsequent clearance of psoriasis. The decrease in the lesional hemoglobin index and the clearance time appeared to be dose-dependent, and, indeed, a more aggressive regimen resulted in approximately 50% reduction in both the number of treatments and the cumulative dose required to achieve a stable hemoglobin index ratio and subsequent clinical clearance. |
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Authors:
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K S Ryatt; J W Feather; J B Dawson; J A Cotterill |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the American Academy of Dermatology Volume: 9 ISSN: 0190-9622 ISO Abbreviation: J. Am. Acad. Dermatol. Publication Date: 1983 Oct |
Date Detail:
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Created Date: 1983-12-20 Completed Date: 1983-12-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7907132 Medline TA: J Am Acad Dermatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 558-62 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Erythema / metabolism Female Hemoglobins / analysis Humans Male Melanins / analysis PUVA Therapy* Photochemotherapy* Psoriasis / drug therapy* Skin / analysis Spectrophotometry Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; 0/Melanins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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