Document Detail


The usefulness, in pharmacological classification, of complementary pattern-recognition techniques and structure modelling as afforded by the iterative collation of multiple-trial data in data banks.
MedLine Citation:
PMID:  3885266     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this emerging information age no significant limits can be envisaged to the immense resources of knowledge that pharmacological sciences can draw upon by systematically applying multivariate pattern-recognition techniques to those data banks which can be organized internationally with better standardization of descriptors, i.e. by parametrizing observations and evaluating monitoring in experimental, biological assays, clinical trials and postmarketing surveillance. Even conventionally or habitually adopted references and communalities such as traditional drug profiles and receptor models may be iteratively re-checked and suitably adapted so as to take account of more adequate, up-to-date analytical techniques, fresh biological ideas and new advances in terms of physiological refinements. An attempt may also be made to modify the chemicophysical relationships and patterns currently traced on the basis of what are held to be quantitative structure-activity oversimplifications. The present paper focuses upon specifying a number of standardization criteria in conventional assays and upon submitting multiple biological features to monitoring; in addition, it gives some picture of the new trends the approach can offer and draws attention to the more relevant, innovative literature references.
Authors:
M L Cingolani; L Re; L Rossini
Related Documents :
18477596 - Supporting grid-based clinical trials in scotland.
14689186 - Advantage of single-trial models for response to selection in wheat breeding multi-envi...
18313556 - Efficient ways exist to obtain the optimal sample size in clinical trials in rare disea...
12094756 - Proportional hazards models with random effects to examine centre effects in multicentr...
19833376 - The analysis of pollutant profiles by means of compositional analysis. an application t...
22329556 - Missing data in substance abuse treatment research: current methods and modern approaches.
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Pharmacological research communications     Volume:  17     ISSN:  0031-6989     ISO Abbreviation:  Pharmacol Res Commun     Publication Date:  1985 Jan 
Date Detail:
Created Date:  1985-05-17     Completed Date:  1985-05-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0236354     Medline TA:  Pharmacol Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-22     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Clinical Trials as Topic
Drug Evaluation, Preclinical
Guinea Pigs
Humans
Information Systems*
Models, Theoretical
Pattern Recognition, Automated*
Pharmacology*
Product Surveillance, Postmarketing
Rats
Receptors, Drug
Software
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Receptors, Drug

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Development of antibody-mediated extraction followed by GC/MS (antibody/GC/MS) and its application t...
Next Document:  Noise transfer in screen-film subtraction radiography.